| 摘要: |
| ［摘要］ 目的 观察盐酸伐昔洛韦颗粒联合双黄连口服液治疗儿童水痘的临床疗效。方法 将该院2016-05～2017-04治疗的水痘患儿86例随机分为对照组与观察组，每组43例。对照组给予盐酸伐昔洛韦颗粒治疗，规格：150 mg/包，5～10 mg/(kg·d)，2次/d。观察组在对照组基础上加用双黄连口服液进行治疗，规格10 ml/支（相当于饮片7.5 g），1～3岁10 ml/次，3次/d，4～7岁20 ml/次，3次/d，3 d为一个疗程。两组均治疗3 d。观察并记录两组患儿症状改善时间、疗效及不良反应情况。结果 观察组显效20例，有效19例，无效4例。对照组显效9例，有效27例，无效7例。观察组疗效优于对照组（P<0.05）。患儿临床症状消失时间明显短于对照组（P<0.05）。两组患儿不良反应发生率差异无统计学意义（P>0.05）。结论 盐酸伐昔洛韦颗粒联合双黄连口服液治疗儿童水痘疗效显著，缩短了临床症状改善时间，适合临床推广应用。 |
| 关键词: 水痘 盐酸伐昔洛韦颗粒 双黄连口服液 |
| DOI：10.3969/j.issn.1674-3806.2018.03.21 |
| 分类号:R 725.6 |
| 基金项目: |
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| Clinical effect of valacyclovir hydrochloride granules combined with Shuanghuanglian oral solution on varicella in 86 cases of children |
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WANG Ling-yan
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Department of Pediatrics, the People′s Hospital of Changle County, Shandong 262400, China
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| Abstract: |
| ［Abstract］ Objective To observe the clinical efficacy of valacyclovir hydrochloride granules combined with Shuanghuanglian oral solution in treatment of varicella in children.Methods 86 children with varicella treated from May 2016 to April 2017 were randomly divided into the control group and the observation group, with 43 cases in each group. The control group was treated with valacyclovir hydrochloride granules, 5～10 mg/ kg·d, bid. The observation group was treated with the same treatment as the control group plus Shuanghuanglian oral liquid 10 ml, tid(1～3 years old), 20 ml, tid(4～7 years old). Both of the two groups were treated for 3 days. The symptom improvement time, clinical efficacy and adverse reactions were compared between the two groups.Results In the observation group, 20 cases were markedly effective, 19 effective, and 4 ineffective. In the control group, the clinical outcome was markedly effective in 9 cases, effective in 27 cases, and ineffective in 7 cases. The curative effect of the observation group was better than that of the control group(P<0.05). The disappearance time of clinical symptoms was significantly shorter than that of the control group（P<0.05）. There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Valacyclovir hydrochloride granule combined with Shuanghuanglian oral solution is effective in treatment of varicella in children. It can shorten the time for symptom improvement. |
| Key words: Chicken pox Valacyclovir hydrochloride granules Shuanghuanglian oral liquid |
