| 摘要: |
| ［摘要］ 目的 比较人与Balb/c小鼠口腔癌形成及颌下淋巴结转移过程中E-钙黏蛋白（E-cadherin）的表达情况。方法 采用免疫组化法检测人（24例）和小鼠（12例）正常口腔黏膜组织、口腔上皮异常增生组织、口腔鳞癌组织及口腔鳞癌颌下淋巴结转移灶中E-cadherin的表达情况。结果 人正常口腔黏膜E-cadherin的表达率为100.0%（24/24），口腔上皮异常增生组织E-cadherin表达率为87.5%(21/24)，口腔鳞癌E-cadherin表达率为0.0%(0/24)，颌下淋巴结转移灶中E-cadherin表达率为79.2%(19/24)。小鼠正常口腔黏膜E-cadherin的表达率为100.0%（12/12），口腔上皮异常增生组织E-cadherin表达率为83.3%(10/12)，口腔鳞癌E-cadherin表达率为0.0%(0/12)，颌下淋巴结转移灶中E-cadherin表达率为100.0%（12/12）。结论 E-cadherin的表达在人与小鼠具有相似性，随着病理恶性程度的升高，人和小鼠口腔癌各阶段组织中E-cadherin的表达率逐渐降低，但在颌下淋巴结转移灶中表达率升高，表明E-cadherin是参与口腔癌发生、发展及颌下淋巴结转移过程中的一个重要因子。 |
| 关键词: E-钙黏蛋白 口腔鳞状细胞癌 淋巴结转移 小鼠 人 |
| DOI：10.3969/j.issn.1674-3806.2018.11.07 |
| 分类号:R 739.85 |
| 基金项目:国家自然科学基金资助项目（编号：81360407）；广西自然科学基金资助项目（编号：2013GXNSFAA019182） |
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| Comparison of E-cadherin expressions between human and mouse in the occurrence, development and lymph node metastasis of oral squamous cell carcinoma |
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CHENG Li, LI Jing, GUO Meng-zhu, et al.
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Department of Oral and Maxillofacial Surgery, the Affiliated Stomatological Hospital of Guangxi Medical University, Nanning 530021, China
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| Abstract: |
| ［Abstract］ Objective To compare the expressions of E-cadherin in different oral carcinogenesis stages and lymph node metastasis between human and mouse models. Methods Immunohistochemical staining was used to detect the expressions of E-cadherin in normal oral mucosae, oral dysplasia, oral squamous cell carcinomas(OSCC) and lymph node metastases in human beings(n=24) and mice(n=12), respectively. Results The expression rates of E-cadherin in normal oral mucosa, dysplasia, OSCC and lymph node metastasis were 100.0%, 87.5%, 0.0% and 79.2% in human beings and 100.0%, 83.3%, 0.0% and 100.0% in mice. Conclusion The expressions of E-cadherin are similar in the same pathological stages of human beings and mice respectively. The expression rates of E-cadherin are decreased gradually in both human beings and mice with the increased degree of pathological malignancy, but are increased in lymph node metastases. These results indicate that E-cadherin may play an important role in the occurrence and development of OSCC and submandibular lymphatic node metastase. |
| Key words: E-cadherin Oral squamous cell carcinoma(OSCC) Lymph node metastasis Mouse Human |
