| 摘要: |
| ［摘要］ 目的 探讨长链非编码RNA-ROR（lncRNA-ROR）在慢性心力衰竭（CHF）患者血清中的表达水平及临床意义。方法 收集25名正常人（对照组）及109例CHF患者，采用实时荧光定量PCR(real-time PCR)检测两组血清中lncRNA-ROR的表达,分析lncRNA-ROR的表达与N-末端脑钠肽前体（NT-proBNP）、左室舒张末期内径及左心室射血分数的相关性。结果 对照组中lncRNA-ROR的表达水平相对较低，CHF患者中lncRNA-ROR的表达水平明显升高，差异有统计学意义（P<0.05）。相关分析发现lncRNA-ROR的表达水平与CHF心功能分级、左室舒张末期内径及NT-proBNP呈正相关，与左心室射血分数呈负相关（P<0.05）。结论 lncRNA-ROR的表达水平与心力衰竭严重程度相关，有望成为早期诊断CHF的生物学标志物。 |
| 关键词: 心功能分级 慢性心力衰竭 长链非编码RNA-ROR |
| DOI：10.3969/j.issn.1674-3806.2019.04.09 |
| 分类号:R 541.6 |
| 基金项目:河南省科技攻关项目（编号：162102310143） |
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| Expression of long chain noncoding RNA-ROR in serum of patients with chronic heart failure and its clinical significance |
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ZHANG Li-zhen, LIU Shu-zhen, MA Jun, et al.
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Department of Cardiology, the Second Affiliated Hospital of Zhengzhou University, Henan 450014, China
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| Abstract: |
| ［Abstract］ Objective To explore the expression of long chain noncoding RNA-ROR(lncRNA-ROR) in the serum of the patients with chronic heart failure(CHF) and its clinical significance. Methods The expressions of lncRNA-ROR in the serum of 25 healthy subjects(control group) and in 109 patients with CHF were detected by Real-time PCR. The correlation between the expressions of lncRNA-ROR and NT-proBNP, left ventricular end-diastolic diameter and left ventricular ejection fraction was analyzed. Results The expression of lncRNA-ROR in the CHF patients was significantly higher than that in the control group（P<0.05）. The expression of lncRNA-ROR was positively correlated with cardiac functional grading of CHF, left ventricular end-diastolic diameter and NT-proBNP, and was negatively correlated with left ventricular ejection fraction（P<0.05）. Conclusion The expression of lncRNA-ROR is related to the severity of heart failure. lncRNA-ROR is expected to be a biomarker for early diagnosis of CHF. |
| Key words: Cardiac functional grading Chronic heart failure Long chain noncoding RNA-ROR(lncRNA-ROR) |
