| 摘要: |
| ［摘要］ 目的 探讨白介素-6(interleukin 6,IL-6)在人类免疫缺陷病毒(human immunodeficiency virus，HIV)合并马尔尼菲蓝状菌(talaromyces marneffei,TM)感染人群中的表达情况及作用。方法 选择在南宁市第四人民医院未接受抗病毒治疗(antiretroviral therapy，ART)的HIV感染者27例，按是否合并TM感染情况分为HIV+TM组（12例）与HIV组（15例）。比较两组的人口学资料和外周血单核细胞（peripheral blood mononuclear cell,PBMC）中IL-6的表达水平。结果 两组年龄、性别和病毒载量比较差异无统计学意义（P>0.05），HIV+TM组的CD4+ T细胞计数低于HIV组，差异有统计学意义（P=0.018）。HIV+TM组中巨噬细胞（PBMC中的一个亚群）的IL-6表达水平高于HIV组，差异有统计学意义（P=0.039）。结论 HIV+TM组PBMC中的IL-6表达较HIV组高，这可能是导致巨噬细胞免疫过度激活，促进TM感染，影响病程进展的关键因素。 |
| 关键词: 马尔尼菲蓝状菌 人类免疫缺陷病毒 外周血单核细胞 白介素-6 |
| DOI：10.3969/j.issn.1674-3806.2019.05.11 |
| 分类号:R 512.9 |
| 基金项目:国家自然科学基金地区科学基金项目（编号：81560326）；广西自然科学基金面上项目（编号：2018GXNSFAA138002）；广西生物医药协同创新中心研究生创新创业项目（编号：GCICB-IE-2017012、GCICB-IE-2017013） |
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| The expression and effect of IL-6 in HIV and Talaromyces marneffei coinfection patients |
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LUO Chao-lian, XIE Zhi-man, QIN Ying-mei, et al.
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The Key Laboratory of AIDS Prevention and Research & Guangxi Collaborative Innovation Center for Biomedicine, Guangxi Medical University, Nanning 530021, China
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| Abstract: |
| ［Abstract］ Objective To explore the expression and effect of interleukin 6(IL-6) in human immunodeficiency virus(HIV) and Talaromyces marneffei(TM) coinfection patients. Methods Twenty-seven HIV-infected patients who had not received antiretroviral therapy(ART) were selected from the Fourth People′s Hospital of Nanning City, and were divided into HIV+TM group(12 cases) and HIV group(15 cases) according to the infection status of TM. The demographic data and the level of IL-6 in perpheral blood mononuclear cell(PBMC) were compared between the two groups. Results There were no significant differences in age, gender and viral load between the two groups(P>0.05), while the CD4+ T cell count of the HIV+TM group was significantly lower than that of the HIV group(P=0.018). The IL-6 expression level of macrophages(a subgroup of PBMC) in the HIV+TM group was significantly higher than that of the HIV group(P=0.039). Conclusion The IL-6 expression of HIV+TM group in PBMC is higher than HIV group, which may lead to immune hyperactivation in macrophages and may be a critical factor to promote TM infection and disease progression. |
| Key words: Talaromyces marneffei(TM) Human immunodeficiency virus(HIV) Perpheral blood mononuclear cell(PBMC) Interleukin 6(IL-6) |
