| 摘要: |
| ［摘要］ 乌索酸及其同分异构体齐墩果酸是一种广泛存在于植物中的五环三萜类化合物。近来的研究逐渐揭示乌索酸和齐墩果酸对各种疾病的治疗作用，而在防治2型糖尿病及相关并发症中的疗效尤为显著，例如非酒精性脂肪性肝炎、肾病、视网膜病变、动脉粥样硬化等，并且随着研究的深入，乌索酸和齐墩果酸对疾病治疗作用的相关分子机制也逐渐得到揭示。随着全世界范围内2型糖尿病发病率的急速增加，2型糖尿病已经成为人们主要关注的疾病之一。靶向治疗2型糖尿病中改变的信号通路可以有效地防治糖尿病及其并发症，天然及衍生型的乌索酸和齐墩果酸是改善这些通路的潜在治疗药物。该研究从有关这些化合物的体内外试验中揭示以下发现：（1）改善胰岛素信号，减少高血糖症；（2）通过上调抗氧化剂减少氧化应激；（3）通过抑制促炎性因子减少炎症反应。该文通过讨论这些治疗作用的分子机制，为应用乌索酸和齐墩果酸防治2型糖尿病及相关并发症提供理论依据。 |
| 关键词: 乌索酸 2型糖尿病 氧化应激 炎症反应 |
| DOI：10.3969/j.issn.1674-3806.2019.07.02 |
| 分类号:R 587.1 |
| 基金项目:国家自然科学基金项目（编号：81770724）；沈阳市中青年科技创新人才支持计划项目（编号：RC170172） |
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| Advances in the molecular mechanisms of ursolic acid and its isomer oleanolic acid on treatment of type 2 diabetes and assciated complications |
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XU Li, FAN Qiu-ling
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Department of Nephrology, the First Affiliated Hospital of China Medical University, Shenyang 110001, China
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| Abstract: |
| ［Abstract］ Ursolic acid(UA) and its isomer, oleanolic acid(OA) are one of the pentacyclic triterpenes which are a group of widespread natural compounds. Recently, UA and OA have received great attention on the benefits of prevention and treatment of type 2 diabetes and associated complications, such as nonalcoholic fatty liver disease, nephropathy, retinopathy, and atherosclerosis. With the development of research, the molecular mechanisms of UA and OA on the treatment of diseases have been gradually expounded. The prevalence of type 2 diabetes has been an issue of major concern in countries world-wide since it reached the global epidemic levels. Treatments targeting the altered signaling pathways in type 2 diabetes may effectively prevent diabetes and its complications. Natural and derived UA and OA are the potential therapeutic agents to modulate these pathways. We reveal the following findings from in vitro and in vivo studies of these compounds: (1)improving insulin signal and reducing hyperglycemia; (2)reducing oxidative stress by upregulating antioxidants; (3)reducing inflammatory response by inhibiting proinflammatory cytokines. In this paper, we discuss the molecular mechanisms of these therapeutic effects to provide the theoretical basis for application of UA and OA in the prevention and treatment of type 2 diabetes and assciated complications. |
| Key words: Ursolic acid Type 2 diabetes Oxidative stress Inflammation |
