| 摘要: |
| ［摘要］ 目的 通过分析特发性膜性肾病（IMN）患者血清25-羟基维生素D［25(OH)D］与临床指标、肾脏病理的相关性，进一步探究25(OH)D在IMN发病过程中的临床意义。方法 选取60名健康人及194例IMN患者，检测其25(OH)D水平、临床指标，并记录IMN患者首次肾穿病理资料，根据25(OH)D水平分为缺乏组和不足组，比较两组临床及病理指标的差异，并采用Logistic回归分析筛查影响25(OH)D的因素。结果 IMN组的25(OH)D水平显著低于健康组（P<0.01）。25(OH)D缺乏组的24 h尿蛋白（24h UP)、血肌酐（Cr）、肾小球基底膜（GBM）厚度均高于不足组，血白蛋白（ALB）、血红蛋白（Hb）低于不足组，差异有统计学意义（P<0.05）。Logistic回归分析结果表明，24h UP、GBM厚度是25(OH)D水平的影响因素。结论 IMN组的25(OH)D水平显著低于健康组；24h UP、GBM厚度可能是影响IMN患者25(OH)D水平的主要因素。 |
| 关键词: 特发性膜性肾病 膜性肾病 25-羟基维生素D 肾活检 肾脏病理 |
| DOI：10.3969/j.issn.1674-3806.2019.07.05 |
| 分类号:R 692 |
| 基金项目:广西重点研发计划项目（编号：桂科AB16380229）；南宁市青秀区科技局重点研发计划项目（编号：2018030） |
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| Analysis on the related factors of serum 25-hydroxyvitamin D level in patients with idiopathic membranous nephropathy |
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YE Kun, LÜ Xia, WU Qiu-xia
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Department of Nephrology, the People′s Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021, China
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| Abstract: |
| ［Abstract］ Objective To explore the clinical significance of 25-hydroxyvitamin D［25(OH)D］ in pathogenesis of idiopathic membranous nephropathy(IMN) by analyzing the correlation between serum 25(OH)D and clinical indicators and renal pathology in patients with IMN. Methods Sixty healthy subjects and 194 IMN patients were enrolled. The 25(OH)D levels and clinical indexes were detected. The pathological data of the first renopuncture in IMN patients were recorded. According to the 25(OH)D levels, the patients were divided into the deficiency group and the insufficiency group. The differences in the clinical and pathological indexes were compared between the two groups, and Logistic regression analysis was used to screen for the factors affecting 25(OH)D. Results The level of 25(OH)D in the IMN group was significantly lower than that in the healthy group(P<0.01). The amount of 24-hour urine protein(24h UP), the serum creatinine(Cr) value and the glomerular basement membrane(GBM) thickness in the 25(OH)D deficiency group were higher than those in the insufficiency group. The levels of serum albumin(ALB) and hemoglobin(Hb) in the 25(OH)D deficiency group were significantly lower than those in the insufficiency group(P<0.05). Logistic regression analysis showed that 24h UP and GBM thickness were the influencing factors of the 25(OH)D level. Conclusion The 25(OH)D level in the IMN group is significantly lower than that in the healthy group. The 24h UP, GBM thickness may be the main factors affecting the 25(OH)D level of patients with IMN. |
| Key words: Idiopathic membranous nephropathy(IMN) Membranous nephropathy 25-hydroxyvitamin D［25(OH)D］ Renal biopsy Renal pathology |
