| 摘要: |
| ［摘要］ 目的 探讨妊娠期糖尿病（GDM）患者血清脂肪特异性丝氨酸蛋白酶抑制剂（vaspin）水平的变化及其与炎症因子肿瘤坏死因子α（TNF-α）、白介素6（IL-6）的相关性。方法 选取2016-10～2017-12于菏泽市立医院产科门诊行常规产前检查的孕妇120例，按75 g葡萄糖耐量试验（OGTT）结果，分为GDM组60例，糖耐量正常妊娠（GNGT）组60例。采用酶联免疫吸附法（ELISA）测定空腹血清vaspin、TNF-α、IL-6水平并进行统计学分析。结果 GDM组血清vaspin、TNF-α、IL-6水平均显著高于GNGT组（P<0.05）。线性相关分析显示，vaspin与孕前体质量指数（BMI）、BMI增加幅度、血清胰岛素（FINS）、稳态模型胰岛素抵抗指数（HOMA-IR）呈显著正相关（P<0.05），与TNF-α、IL-6呈显著负相关（P<0.05）。多元线性回归分析显示，孕前BMI、TNF-α、IL-6和HOMA-IR是血清vaspin的独立影响因素（P<0.05）。结论 GDM患者血清vaspin、TNF-α、IL-6水平均升高，vaspin可能代偿性参与了肥胖、胰岛素抵抗及GDM的发生发展，同时vaspin有抑制炎症反应的作用。 |
| 关键词: 脂肪特异性丝氨酸蛋白酶抑制剂 妊娠期糖尿病 炎症因子 胰岛素抵抗 |
| DOI：10.3969/j.issn.1674-3806.2019.07.09 |
| 分类号:R 714 |
| 基金项目:荷泽市立医院科研项目（编号：20150302） |
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| Changes of serum vaspin levels in patients with gestational diabetes mellitus and its correlation with inflammatory factors |
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ZHU Hui-jing, ZHU Xin, XIE He-lan, et al.
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Department of Endocrinology, Heze Municipal Hospital, Shandong 274031, China
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| Abstract: |
| ［Abstract］ Objective To explore the changes of serum vaspin levels in patients with gestational diabetes mellitus(GDM) and its correlation with inflammatory factors of tumor necrosis factor-alpha(TNF-α) and interleukin-6(IL-6). Methods One hundred and twenty pregnant women undergoing prenatal examination in the Obstetrical Out-patient Clinic of Heze Municipal Hospital from October 2016 to December 2017 were selected. The 120 pregnant women were divided into GDM group(n=60) and normal glucose tolerance(GNGT) group(n=60) according to their different oral glucose tolerance test(OGTT) results. The levels of fasting serum vaspin, TNF-α and IL-6 were detected by enzyme-linked immunosorbent assay(ELISA), and statistical analysis was conducted. Results The serum levels of vaspin, TNF-α and IL-6 in the GDM group were significantly higher than those in the GNGT group(P<0.05).Correlation analysis showed that vaspin was positively correlated with pre-gestational body mass index(BMI), increment of BMI during pregnancy, fasting insulin(FINS) and homeostasis model assessment of insulin resistance(HOMA-IR) but negatively correlated with TNF-α and IL-6（P<0.05）. In a multiple linear regression analysis，pre-gestational BMI, TNF-α, IL-6 and HOMA-IR were independent risk factors of serum vaspin concentrations. Conclusion Serum levels of vaspin, TNF-α and IL-6 in GDM patients are increased. Vaspin may be compensatory in the occurrence and development of obesity, insulin resistance and GDM, and can inhibit the inflammatory response. |
| Key words: Vaspin Gestational diabetes mellitus(GDM) Inflammatory factors Insulin resistance |
