| 摘要: |
| ［摘要］ 目的 探讨肺腺癌患者表皮生长因子受体（EGFR）突变状态与CT影像学及临床特征的关联性。方法 收集2016-06～2017-12就诊并行EGFR基因检测的149例肺腺癌患者（突变80例，野生型69例）CT影像学及临床资料，比较EGFR突变组与野生型组的CT影像学及临床特征。结果 临床特征：女性、无吸烟史、癌胚抗原（CEA）升高的患者EGFR突变率高（P<0.05）。CT影像学：肿瘤伴有毛刺、胸腔积液的患者EGFR突变率高（P<0.05）。Logistic回归分析结果提示性别、CEA、毛刺对EGFR突变有预测价值。结论 单因素分析结果提示EGFR突变状态与性别、吸烟史、CEA、毛刺及胸腔积液有关联性。Logistic回归分析结果提示女性、CEA升高、毛刺是肺腺癌患者EGFR突变的危险因素。 |
| 关键词: 肺腺癌 表皮生长因子受体突变 CT影像 临床特征 |
| DOI：10.3969/j.issn.1674-3806.2019.07.15 |
| 分类号:R 734；R 445 |
| 基金项目: |
|
| Correlation between EGFR mutation and CT radiological features and clinical characteristics in lung adenocarcinoma |
|
DING Jia-jia, SU Xiang-yu, WANG Cai-lian, et al.
|
|
Department of Oncology, Zhongda Hospital Affiliated to Southeast University, Nanjing 210009, China
|
| Abstract: |
| ［Abstract］ Objective To explore the correlation between epidermal growth factor receptor(EGFR) mutation status and computed tomography(CT) imaging features and clinical characteristics in lung adenocarcinoma. Methods The clinical and CT imaging data of 149 lung adenocarcinoma patients who underwent EGFR gene test were collected in our hospital from June 2016 to December 2017. The patients included 80 cases of mutation and 69 cases of wild type. The CT features and clinical characteristics of the EGFR mutation group and the wild type group were compared. Results Clinical characteristics: the proportion of women with no smoking history and elevated tumor marker carcino-embryonic antigen(CEA) in the EGFR mutation group was higher than that in the EGFR-free group(P<0.05). CT imaging features: the mutation rate of EGFR in the patients with tumor accompanied by burr and pleural effusion was high(P<0.05). Logistic regression analysis showed that gender, tumor marker CEA and spicule sign of CT imaging had predictive value for EGFR mutation in lung adenocarcinoma. Conclusion Univariate analysis results suggest that EGFR mutation status of lung adenocarcinoma is related to the patients′ gender, smoking history, tumor marker CEA, burr sign and pleural effusion. Logistic regression models suggest that female, elevated CEA and burr signs are risk factors of EGFR mutation in patients with lung adenocarcinoma. |
| Key words: Lung adenocarcinoma Epidermal growth factor receptor(EGFR) mutation Computed tomography(CT) imaging Clinical characteristics |
