| 摘要: |
| ［摘要］ 目的 评价噻吗洛尔外用治疗婴幼儿血管瘤（infantile hemangiomas，IH）的疗效与安全性,为临床用药提供循证依据。方法 计算机全面检索维普数据库（VIP）、万方数据库（WanFang Data）、中国知网数据库（CNKI）、中国生物医学文献数据库（CBM）、PubMed、Embase、Cochrance library、Medline中关于噻吗洛尔外用治疗IH的随机对照试验，检索时间由建库至2019-01，所筛文献经纳入、排除标准后采用RevMan 5.3软件进行Meta分析，对纳入文献均进行文献质量评价及偏倚风险评估，并探究噻吗洛尔治疗IH的有效性及安全性。结果 最终纳入11篇文献，Meta分析结果：（1）噻吗洛尔有效率显著高于安慰剂和空白对照［RR=2.79, 95%CI（2.13，3.65), P<0.01］，不良反应差异无统计学意义［RR=2.46，95%CI（0.40，15.22），P=0.33］；（2）噻吗洛尔与普萘洛尔相比，有效率差异无统计学意义［RR=1.08，95%CI（0.88，1.31），P=0.47］，噻吗洛尔不良反应发生率更低［RR=0.29，95%CI（0.19，0.46），P<0.01］。结论 基于现有数据分析，噻吗洛尔外用治疗IH显著有效，有效率与普萘洛尔无明显差异，不良反应发生率相对更低。 |
| 关键词: 噻吗洛尔 婴幼儿血管瘤 随机对照试验 Meta分析 |
| DOI：10.3969/j.issn.1674-3806.2019.08.07 |
| 分类号:R 739.5 |
| 基金项目:贵州省卫健委科学技术基金项目（编号：gzwjkj2018-1-078） |
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| Topical timolol in treatment of infantile hemangiomas: a meta-analysis |
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HU Teng, FENG Hong-chao, SHAO Min
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Guizhou Medical University, Guiyang 550004, China
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| Abstract: |
| ［Abstract］ Objective To evaluate the efficacy and safety of topical timolol in treatment of infantile hemangiomas(IH) and to provide evidence-based basis for the clinical medication. Methods A comprehensive computer-based search of VIP, WanFang Data, CNKI, CBM, PubMed, Embase, Cochrance library and Medline was conducted to collect the randomized controlled trials(RCTs) about the treatment of IH with topical timolol from the date of inception to January 2019, and each study was screened strictly according to the inclusion criteria to perform a meta-analysis using the software RevMan 5.3. The literature quality and the risk of bias were assessed in all included references, and the efficacy and safety of timolol in IH treatment were explored. Results Eleven literatures were included and the meta-analysis results were as follows: （1） Timolol was more effective than placebo and blank control［RR=2.79, 95%CI(2.13, 3.65), P<0.01］, and there was no significant difference in adverse reactions among the groups［RR=2.46, 95%CI(0.40, 15.22), P=0.33］; （2）There was no significant difference in effective rate between timolol and propranolol［RR=1.08, 95%CI(0.88, 1.31), P=0.47］, but timolol had a lower incidence of adverse reactions than propranolol［RR=0.29, 95%CI(0.19, 0.46), P<0.01］. Conclusion Data analysis based on existing data shows that the topical treatment of timolol for IH is significantly effective, and there is no significant difference in effective rate between timolol and propranolol, but timolol has a lower incidence of adverse reactions. |
| Key words: Timolol Infantile hemangiomas(IH) Randomized controlled trials(RCTs) Meta-analysis |
