| 摘要: |
| ［摘要］ 细胞内存在成千上万种非编码RNA（non-coding RNA，ncRNA），人们对ncRNA的认识从最初的转录垃圾已转变为功能调控分子。ncRNA参与介导细胞过程，包括染色质重构、转录、转录后修饰，在许多疾病中扮演着关键调控因子，特别是在恶性肿瘤中可作为致癌因子和抑癌因子驱动特定的细胞生物活动。迄今为止，卵巢癌的发病病因尚不明确，探索ncRNA在卵巢癌细胞中的作用及机制，有助于为卵巢癌的研究提供新的思路。现就卵巢癌相关的ncRNA的研究现状，尤其是微小RNA（miRNA）、长链非编码RNA（lncRNA）及环状RNA（circRNA）作一综述。 |
| 关键词: 卵巢癌 非编码RNA 机制 |
| DOI：10.3969/j.issn.1674-3806.2020.02.27 |
| 分类号:R 737.31 |
| 基金项目:2018年度研究生创新专项资金立项项目（编号：YC2018-X004） |
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| Research status of non-coding RNA in ovarian cancer |
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ZHANG Min, DU Yu-xuan, WANG Yang, et al.
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Gannan Medical University, Jiangxi 341000, China
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| Abstract: |
| ［Abstract］ There are tens of thousands of non-coding ribonucleic acid(non-coding RNA,ncRNA) in cells. People′s understanding of ncRNA has changed from the initial transcription junk into functional regulators. Non-coding RNA is involved in mediating cell processes, including chromatin remodeling, transcription and post-transcriptional modification. Non-coding RNA plays a key regulatory role in many diseases, especially in malignant tumors, it can drive specific cellular biological activities as carcinogenic and anti-carcinogenic factors. So far, the etiology of ovarian cancer has not been clearly elucidated. Exploring the role and mechanism of ncRNA in ovarian cancer cells will help to provide new ideas for the study of ovarian cancer. In this paper, we review the studies on ncRNA associated with ovarian cancer, focusing on microRNA(miRNA), long non-coding RNA(lncRNA) and circular RNA(circRNA). |
| Key words: Ovarian cancer Non-coding ribonucleic acid(ncRNA) Mechanism |
