| 摘要: |
| ［摘要］ 炎性小体是先天免疫系统的重要组成部分，其中研究热点为NOD样受体蛋白3（NOD-like receptor protein 3,NLRP3）炎性小体，通过激活相应的信号途径参与多种慢性炎症疾病的发生发展。近年来，NLRP3炎性小体在动脉粥样硬化、非酒精性脂肪性肝病、阿尔茨海默病、慢性阻塞性肺疾病和慢性肾脏病等疾病的发生进程中，发挥着重要作用。该文就炎性小体与慢性炎症相关疾病的研究进展作一综述。 |
| 关键词: 炎性小体 NOD样受体蛋白3 炎症 慢性疾病 |
| DOI：10.3969/j.issn.1674-3806.2020.07.23 |
| 分类号:R 54 |
| 基金项目:国家自然科学基金面上项目（编号：81670258，81873515）；福建省自然科学基金面上项目（编号：2017J01247） |
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| Research progress in inflammasome NLRP3 and chronic inflammatory related diseases |
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LIN Kai-ling, XUE Yan, YU Hui-zhen
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Key Laboratory of Geriatrics, Provincial Clinical Medical College of Fujian Medical University, Fuzhou 350001, China
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| Abstract: |
| ［Abstract］ Inflammasomes are important components of the innate immune system, among which NOD-like receptor protein 3(NLRP3) is a research hotspot. NLRP3 is involved in the occurrence and development of various chronic inflammatory diseases by activating the corresponding signaling pathways. Recent researches demonstrate that inflammasome NLRP3 plays a vital role in the pathogenesis of various diseases, such as atherosclerosis(AS), non-alcoholic fatty liver disease(NAFLD), Alzheimer ′s disease(AD), chronic obstructive pulmonary disease(COPD) and chronic renal disease. In this paper, we review the research progress of inflammasomes and chronic inflammatory related diseases. |
| Key words: Inflammasomes NOD-like receptor protein 3(NLRP3) Inflammation Chronic disease |
