| 摘要: |
| ［摘要］ 目的 分析一起新型冠状病毒肺炎（COVID-19）家庭聚集性疫情的流行病学及临床特征，为进一步做好防控工作提供依据。方法 （1）流行病学调查：通过向患者本人、家属以及其他知情人员（医务人员）进行电话、面对面访谈，收集所有患者暴露史、家庭聚集性发病情况、医学/家庭隔离情况。（2）临床资料收集：通过查阅病历、向患者本人及家属询问病史，收集患者一般情况、临床症状、体征、实验室检查、影像学结果、治疗方案、疾病转归及近期预后。结果 （1）1个家庭共11例COVID-19确诊患者，具有与武汉疫区确诊COVID-19指示病例直接或间接密切接触、共同生活流行病学特征。（2）11例COVID-19确诊患者均无重症患者，儿童临床表现轻且不典型。（3）经治疗达出院标准COVID-19患者出院后有4例新型冠状病毒（SARS-CoV-2）核酸复阳，1例成人症状轻微，3例儿童均无症状。结论 （1）聚集性发病是该次疫情的重要流行特征，家庭内密切接触是儿童COVID-19感染主要方式。（2）出院后SARS-CoV-2核酸复阳性并不能用于评估疾病严重程度。 |
| 关键词: 新型冠状病毒肺炎 家庭聚集 流行病学 临床特征 |
| DOI：10.3969/j.issn.1674-3806.2020.12.16 |
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| Analysis of the epidemiological and clinical characteristics of a 2019 corona virus disease family cluster |
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WEN Zhi-hong, TANG Hui-he,WANG Bang-qin, et al.
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Department of Pediatrics, the People′s Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021, China
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| Abstract: |
| ［Abstract］ Objective To investigate the epidemiological and clinical characteristics of a 2019 corona virus disease(COVID-19) family cluster, so as to provide evidence for further prevention and control efforts. Methods (1)Epidemiological investigation: all the information of exposure histories, family clusters, and medical/home isolation was collected through telephone and face-to-face interviews with the patients, family members, and other informed persons(medical personnel). (2)Clinical data collection: the patients′ general condition, clinical symptoms, signs, laboratory examinations, imaging results, treatment planes, disease outcomes and short-term prognoses were collected by consulting the medical records and inquiring the medical history of the patients and their family members. Results (1)There were 11 confirmed COVID-19 cases in the family, with the epidemiological characteristics of living together in close direct or indirect contact with the COVID-19 index cases confirmed in the epidemic area of Wuhan. (2)None of the 11 confirmed cases of COVID-19 had severe symptoms, and the clinical manifestations of the children were mild and atypical. (3)After treatment, severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) nucleic acid was retested to be positive in 4 COVID-19 patients who were discharged from the hospital because of meeting discharge criteria, of whom, 1 adult had mild symptoms and 3 children had no symptoms. Conclusion (1)Clustering is an important epidemic feature of this outbreak, and close family contact is the main form of COVID-19 infection in children. (2)The positive results of SARS-CoV-2 nucleic acid retest after discharge can not be used to assess the severity of the disease. |
| Key words: 2019 corona virus disease(COVID-19) Family cluster Epidemiology Clinical characteristics |
