| 摘要: |
| ［摘要］ 目的 探讨不同不育类型患者精液质量情况及其对补救卵胞浆内单精子注射术（R-ICSI）临床结局的影响。方法 回顾性研究2014-01～2018-12于广西壮族自治区人民医院生殖医学与遗传中心行常规体外受精-胚胎移植（IVF-ET）失败而进行R-ICSI治疗的98对不孕不育夫妇的临床资料。根据不育类型将98对夫妇分为原发性不育组（n=56）和继发性不育组（n=42）。比较两组的一般情况、精液质量、胚胎发育情况及临床结局。结果 继发性不育组前向运动精子百分率大于原发性不育组，精子DNA断裂指数（DFI）小于原发性不育组，两组比较差异有统计学意义（P<0.05）。但两组患者在精液体积、精子浓度、精子总数、精子正常形态率、精子顶体完整率及精子自发顶体反应率方面比较差异均无统计学意义（P>0.05）。两组患者受精率、卵裂率、优胚率、活产率、早产率、流产率、单胎率及双胎率差异均无统计学意义（P>0.05）。两组患者临床妊娠率比较差异有统计学意义（P<0.05）。结论 原发性不育患者精液质量较差，临床妊娠率较低，在行生殖助孕诊疗时，需把不育类型列入考虑范畴。 |
| 关键词: 原发性不育 继发性不育 精液质量 补救卵胞浆内单精子注射术 临床结局 |
| DOI：10.3969/j.issn.1674-3806.2021.01.06 |
| 分类号:R 698.2 |
| 基金项目:国家自然科学基金项目（编号：81360107）；广西自然科学基金项目（编号：2019GXNSFAA185056）；广西卫健委科研课题（编号：Z20170376）；南宁市青秀区科技计划项目（2020030） |
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| Comparison of semen qualities in patients with different types of infertility and their effects on clinical outcomes of rescue intracytoplasmic sperm injection |
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CHEN Qi-gui, LI Da-wen, CHENG Jun-ping, et al.
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Guangxi Medical University, Nanning 530021, China
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| Abstract: |
| ［Abstract］ Objective To investigate the semen qualities of the patients with different types of infertility and their effects on the clinical outcomes of rescue intracytoplasmic sperm injection(R-ICSI). Methods The clinical data of 98 infertile couples who failed in routine in vitro fertilization and embryo transfer(IVF-ET) and received R-ICSI treatment in the Center for Reproductive Medicine and Genetics, the People′s Hospital of Guangxi Zhuang Autonomous Region from January 2014 to December 2018 were retrospectively analyzed. According to the types of infertility, the 98 couples were divided into primary infertility group(n=56) and secondary infertility group(n=42). The general conditions, semen quality, embryo development and clinical outcomes were compared between the two groups. Results The sperm progressive motility in the secondary infertility group was higher than that in the primary infertility group, and the sperm DNA fragmentation index(DFI) in the secondary infertility group was lower than that in the primary infertility group, and the differences were statistically significant between the two groups(P<0.05). However, there were no significant differences between the two groups in terms of semen volume, sperm concentration, total number of sperm, normal sperm morphology rate, sperm acrosome integrity rate and sperm spontaneous acrosome reaction rate(P>0.05). There were no significant differences in the fertilization rate, cleavage rate, excellent embryo rate, live birth rate, premature birth rate, abortion rate, single birth rate and twin birth rate between the two groups(P>0.05). There was significant difference in the clinical pregnancy rate between the two groups(P<0.05). Conclusion The semen quality of primary infertility patients is poor, and their clinical pregnancy rate is low. The types of infertility should be taken into consideration in diagnosis and treatment of reproductive assisted pregnancy. |
| Key words: Primary infertility Secondary infertility Semen quality Rescue intracytoplasmic sperm injection(R-ICSI) Clinical outcome |
