| 摘要: |
| ［摘要］ 目的 分析肝硬化患者并发门静脉血栓（PVT）的危险因素，为PVT的早诊早治提供临床依据。方法 收集2018-01～2020-12广西壮族自治区人民医院消化内科收治的170例肝硬化患者的临床病历资料，其中34例合并PVT为PVT组，另136例未合并PVT为对照组。比较两组患者在人口学资料、病因、实验室检查、影像学检查等方面的差异，采用多因素logistic回归模型探讨肝硬化患者并发PVT的危险因素。结果 PVT组的门静脉主干宽度、凝血酶原时间（PT），以及脾切除术、自发性腹膜炎、Child-Pugh评分为C级的人数比例大于对照组，差异有统计学意义（P<0.05）。多因素logistic回归分析结果显示，PT延长和合并自发性腹膜炎是肝硬化并发PVT的危险因素。结论 PT延长和合并自发性腹膜炎是肝硬化患者并发PVT的危险因素，临床医师应注意对此类患者进行筛查、随访。 |
| 关键词: 肝硬化 门静脉血栓 危险因素 |
| DOI：10.3969/j.issn.1674-3806.2021.04.07 |
| 分类号:R 575.2 |
| 基金项目:广西科技计划项目（编号：桂科AD17129027）；国家自然科学基金项目（编号：82060104）；广西卫健委科研课题（编号：Z20190348） |
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| Analysis on the risk factors of portal vein thrombosis in patients with liver cirrhosis |
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ZHOU Qing-nan, ZHANG Guo, NONG Bing, et al.
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Department of Gastroenterology, the People′s Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021,China
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| Abstract: |
| ［Abstract］ Objective To analyze the risk factors of portal vein thrombosis(PVT) in patients with liver cirrhosis, and to provide clinical basis for early diagnosis and treatment of PVT. Methods The data of clinical medical records of 170 liver cirrhosis patients admitted to the Department of Gastroenterology, the People′s Hospital of Guangxi Zhuang Autonomous Region from January 2018 to December 2020 were collected. Among them, 34 patients with PVT were taken as the PVT group, and the other 136 patients without PVT as the control group. The differences in demographic data, etiology, laboratory examination, imaging examination and other aspects were compared between the two groups. Multivariate logistic regression model was used to explore the risk factors of PVT in the liver cirrhosis patients. Results The proportion of width of main portal vein, prothrombin time(PT), splenectomy, spontaneous peritonitis, and Child-Pugh class C in the PVT group was greater than that in the control group, and the difference was statistically significant(P<0.05). The results of multivariate logistic regression analysis showed that prolonged PT and complicated spontaneous peritonitis were the risk factors of PVT in liver cirrhosis. Conclusion Prolonged PT and complicated spontaneous peritonitis are the risk factors of PVT in patients with liver cirrhosis, and clinicians should pay attention to screening and follow-up for the patients. |
| Key words: Liver cirrhosis Portal vein thrombosis(PVT) Risk factors |
