| 摘要: |
| ［摘要］ FOXA又称叉头盒转录因子A，最初是从大鼠肝核细胞中发现并提取，分为FOXA1、FOXA2、FOXA3，在胚胎发育、代谢、分化、生长等多个方面发挥着重要作用。近年来研究表明，FOXA在肿瘤代谢、增殖、迁延和转移特别是在上皮间充质转化（EMT）进程中发挥着重要的调节作用。该文对FOXA在消化系统恶性肿瘤中的作用研究进展作一综述。 |
| 关键词: 叉头盒 恶性肿瘤 消化系统 上皮间充质转化 |
| DOI：10.3969/j.issn.1674-3806.2022.02.19 |
| 分类号:R 735 |
| 基金项目:国家自然科学基金项目（编号：82173075） |
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| Research progress on the role of FOXA in malignant tumors of the digestive system |
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HUANG Yang-yuan, WANG Li-yan, CHEN Cai-huang, et al.
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Department of Gastroenterology, Affiliated Hospital of Guilin Medical College, Guangxi 541000, China
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| Abstract: |
| ［Abstract］ FOXA, also known as forkbox transcription factor A, is originally found and extracted from rat hepatocytes and divided into FOXA1, FOXA2 and FOXA3. It plays an important role in embryonic development, metabolism, differentiation, growth and so on. In recent years, studies have shown that FOXA plays an important regulatory role in tumor metabolism, proliferation, extension and metastasis, especially in the process of epithelial-mesenchymal transition(EMT). This paper reviews the research progress on the role of FOXA in malignant tumors of the digestive system. |
| Key words: Forkhead box Malignant tumors Digestive system Epithelial-mesenchymal transition(EMT) |
