| 摘要: |
| ［摘要］ 目的 探讨中性粒细胞与淋巴细胞比值(NLR)和血浆纤维蛋白原(FIB)联合检测诊断胃癌的价值。方法 选取2019年6月至2022年3月苏州市立医院收治的胃癌患者116例（胃癌组），另选择同期健康体检者82名（对照组）。比较两组NLR、FIB水平。分析NLR、FIB水平与胃癌患者TNM分期、淋巴结转移情况的关联性。采用ROC曲线法评估NLR、FIB及两者联合诊断胃癌的效能。结果 胃癌组NLR、FIB水平高于对照组，差异有统计学意义（P<0.05）。胃癌患者NLR、FIB水平与其TNM分期及淋巴结转移情况的关联性不显著（P>0.05）。ROC曲线分析结果显示，NLR、FIB以及两者联合诊断胃癌的AUC值分别为0.692、0.650和0.738。两指标联合诊断胃癌的灵敏度和特异度分别为69.80%、70.70%，诊断效能优于单项指标检测。结论 NLR、FIB联合检测对胃癌的诊断具有一定价值，可提高胃癌的诊断效能，有助于胃癌的早期筛查。 |
| 关键词: 胃癌 中性粒细胞与淋巴细胞比值 纤维蛋白原 诊断价值 |
| DOI：10.3969/j.issn.1674-3806.2022.05.12 |
| 分类号:R 735.2 |
| 基金项目: |
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| The diagnostic value of combined detection of neutrophil to lymphocyte ratio and plasma fibrinogen in gastric cancer |
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CAO Chen-liang, WANG Qing
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Department of Gastrointestinal Surgery, Gusu College of Nanjing Medical University, Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Jiangsu 215000, China
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| Abstract: |
| ［Abstract］ Objective To investigate the value of combined detection of neutrophil to lymphocyte ratio(NLR) and plasma fibrinogen(FIB) in diagnosis of gastric cancer. Methods One hundred and sixteen gastric cancer patients admitted to Suzhou Municipal Hospital from June 2019 to March 2022 were selected as the gastric cancer group, and 82 healthy people receiving physical examination were selected as the control group during the same period. The NLR and FIB levels were compared between the two groups. The correlations of the NLR and FIB levels with TNM stage and lymph node metastasis in the gastric cancer patients were analyzed. The receiver operator characteristic(ROC) curve method was used to evaluate the efficiency of NLR, FIB and their combination in diagnosing gastric cancer. Results The levels of NLR and FIB in the gastric cancer group were higher than those in the control group, and the differences were statistically significant(P<0.05). For the gastric cancer patients, there were no significant correlations of the NLR and FIB levels with their TNM stages and lymph node metastases(P>0.05). The results of ROC curve analysis showed that the area under the curve(AUC) values of NLR, FIB and their combination in the diagnosis of gastric cancer were 0.692, 0.650 and 0.738, respectively. The sensitivity and specificity of the combined diagnosis of the two indicators for gastric cancer were 69.80% and 70.70%, respectively, and their diagnostic efficiency was better than that of each indicator alone. Conclusion The combined detection of NLR and FIB has certain value in the diagnosis of gastric cancer, which can improve the diagnostic efficiency of gastric cancer and is helpful for the early screening of gastric cancer. |
| Key words: Gastric cancer Neutrophil to lymphocyte ratio(NLR) Fibrinogen(FIB) Diagnostic value |
