| 摘要: |
| ［摘要］ 间充质干细胞（MSCs）具有多向分化和旁分泌生物活性因子的功能，从而在免疫调节、抗炎、血管生成和抗凋亡等方面发挥作用，广泛应用于临床的细胞治疗中。MSCs来源的外泌体既可携带MSCs的遗传信息，又比MSCs更易于储存和维持MSCs的功能，有利于多种组织损伤后的修复与再生。该文就MSCs及其外泌体生物学特性及功能、MSCs外泌体在不同疾病中的作用及机制作一综述。 |
| 关键词: 间充质干细胞 外泌体 机制 |
| DOI：10.3969/j.issn.1674-3806.2022.08.22 |
| 分类号:R 329.2 |
| 基金项目:安徽省高校自然科学研究重点项目（编号：KJ2019A1105） |
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| Research progress on the roles of the exosomes of mesenchymal stem cells and their mechanisms |
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YU Jing, XU Li
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School of Medicine, Anhui University of Science and Technology, Huainan 232001, China
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| Abstract: |
| ［Abstract］ Mesenchymal stem cells(MSCs) have the function of multi-directional differentiation and paracrine bioactive factors. Therefore, they play important roles in immune regulation, anti-inflammation, angiogenesis and anti-apoptosis, and have been widely used in clinical cell therapy. MSCs-derived exosomes can not only carry the genetic information of MSCs, but also store and maintain the function of MSCs more easily than MSCs, which is beneficial to the repair and regeneration of various tissues after injury. In this paper, the biological characteristics and function of MSCs and their exosomes, and the roles of the exosomes of MSCs in different diseases and their mechanisms are reviewed. |
| Key words: Mesenchymal stem cells(MSCs) Exosome Mechanism |
