| 摘要: |
| ［摘要］ 巨噬细胞作为机体免疫系统的重要组成部分，其通过能量代谢直接影响宿主体内清除结核分枝杆菌（Mtb）的能力。缺氧诱导因子-1α（HIF-1α）通过影响巨噬细胞内的能量代谢途径来调控细胞对Mtb的免疫应答，在巨噬细胞抗结核免疫中起着重要作用。该文对Mtb感染中HIF-1α对巨噬细胞能量代谢的调控作用研究进展作一综述。 |
| 关键词: 结核分枝杆菌 缺氧诱导因子-1α 巨噬细胞 能量代谢 信号通路 治疗靶点 |
| DOI：10.3969/j.issn.1674-3806.2024.05.20 |
| 分类号:R 392.1 |
| 基金项目:国家自然科学基金项目（编号：82270013） |
|
| Advances in the regulatory effect of hypoxia-inducible factor-1α on energy metabolism of macrophages during Mycobacterium tuberculosis infection |
|
LI Chaowei1, XU Junfa1,2, ZHENG Biying1
|
|
1.Institute of Laboratory Medicine, College of Medical Technology, Guangdong Medical University, Dongguan 523808, China; 2.Laboratory Medicine Center, the First Dongguan Affiliated Hospital of Guangdong Medical University, Dongguan 523710, China
|
| Abstract: |
| ［Abstract］ Macrophages, as an important component of the body′s immune system, directly affect the host′s ability to clear Mycobacterium tuberculosis(Mtb) through energy metabolism. Hypoxia-inducible factor-1α(HIF-1α) regulates the immune response to Mtb by influencing the energy metabolism pathway in macrophages, and plays an important role in the anti-tuberculosis immunity of macrophages. This paper reviews advances in the regulatory effect of HIF-1α on energy metabolism of macrophages during Mtb infection. |
| Key words: Mycobacterium tuberculosis(Mtb) Hypoxia-inducible factor-1α(HIF-1α) Macrophage Energy metabolism Signaling pathway Therapeutic target |
