| 引用本文: | 李新叶,代艳,陆元奉,陆春久,石丰浪,罗裕有,凌光满,刘兴夏.儿童过敏性紫癜的临床研究[J].中国临床新医学,0,():-. |
| Li Xinye,Dai Yan,Lu Yuanfeng,Lu Chunjiu,Shi Fenglang,Luo Yuyou,Ling Guangman,Liu Xingxia.儿童过敏性紫癜的临床研究[J].中国临床新医学,0,():-. |
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| 摘要: |
| 目的：回顾性分析儿童过敏性紫癜（HSP）的诱因、临床表现和实验室检查。研究探讨紫癜性肾炎（HSPN）患儿的危险因素。方法：收集 2013年1月至2017年12月在我科住院的HSP患儿的临床资料和相关实验室检查。将这些患儿分HSPN组和非紫癜性肾炎（HSPWN）组，采用统计学方法比较两组患儿的相关指标。结果：该研究共纳入106例患儿作为研究对象，男66例，女40例，中位年龄7岁。以1-3月和10-12月入院为主。50例（47.17%）患儿找到诱因，以上呼吸道感染为主。101例（95.28%）患儿存在皮肤皮疹，82例（77.36%）表现为混合型，39例（36.79%）累计肾脏。实验室检查中，52.83%患儿白细胞计数升高，73.03%患儿D-二聚体升高，87.34%患儿IgA水平升高。HSPN患儿总胆固醇、肌酐、尿酸、胱抑素C水平高于HSPWN，而内生肌酐清除率和IgA/C3比值则相反。Logistic多因素回归分析发现两组患儿之间总胆固醇水平升高差异有统计学意义。结论：儿童过敏性紫癜春冬季节多见，感染是最常见的诱因；临床表现和实验室检查表现多种多样。总胆固醇水平升高是HSPN患儿的独立危险因素。 |
| 关键词: 儿童 过敏性紫癜 紫癜性肾炎 危险因素 总胆固醇 |
| DOI： |
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| 基金项目:广西壮族自治区卫生厅基金资助项目 |
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| The Clinical Research of Children with Henoch-Sch?nlein Purpura |
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Li Xinye, Dai Yan, Lu Yuanfeng, Lu Chunjiu, Shi Fenglang, Luo Yuyou, Ling Guangman, Liu Xingxia
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the People′s Hospital of Guangxi Zhuang Autonomous Region
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| Abstract: |
| Objective: To retrospectively analyze the incentives, clinical data and laboratory tests of children with Henoch-Sch?nlein Purpura (HSP). And to investigate the risk factors for children with Henoch-Sch?nlein Purpura nephritis (HSPN).Methods: To collect the clinical data and laboratory tests of children with HSP, who were admitted to our department from January 2013 to December 2017.Divide these children into HSPN group and HSP without nephritis (HSPWN) group, and than compare the related indexes of the two groups by statistical methods. Results: 106 children were studied in this research. There were 66 males and 40 females with a median age of 7 years. The main months of hospitalization are from January to March and from October to December. 50 children (47.17%) were found the incentives, which mainly incentive was respiratory infections. 101 cases (95.28%) had skin rash, 82 cases (77.36%) showed mixed type, and 39 cases (36.79%) developed nephritis. In laboratory tests, 52.83% children had elevated white blood cell counts, 73.03% had elevated D-dimers, and 87.34% had elevated IgA levels. The levels of total cholesterol, creatinine, uric acid, and cystatin C in children with HSPN were higher than those of HSPWN, while the creatinine clearance rate and IgA/C3 were opposite lower. Logistic multivariate regression analysis found a statistically significant difference in the increase in total cholesterol levels between these two groups. Conclusion: Most cases of pediatric HSP are occurring in spring and winter, and infection is the most common cause; clinical manifestations and laboratory tests of HSP are diverse. Elevated total cholesterol levels are independent risk factors for children with HSPN. |
| Key words: children, Henoch-Sch?nlein Purpura, Henoch-Sch?nlein Purpura nephritis, Risk Factors, Total Cholesterol |
