| 引用本文: | 蒙丹丽,梁列新,宋怀宇.慢加急性肝衰竭患者粪便胆汁酸谱变化的研究[J].中国临床新医学,0,():-. |
| 蒙丹丽,宋怀宇.慢加急性肝衰竭患者粪便胆汁酸谱变化的研究[J].中国临床新医学,0,():-. |
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| 摘要: |
| 目的 检测慢加急性肝衰竭患者粪便胆汁酸谱水平，了解其在疾病发展中的意义。方法 纳入20名慢加急性肝衰竭患者，随机选取14名健康者作为对照组。应用HPLC法检测两组粪便胆汁酸（胆酸、石胆酸、脱氧胆酸、鹅去氧胆酸、熊去氧胆酸及总胆酸)的水平。结果 慢加急性肝衰竭患者粪便胆酸水平高于正常对照（P＜0.05），石胆酸、脱氧胆酸、鹅去氧胆酸、熊去氧胆酸及总胆汁酸水平与对照组相比无明显统计学差异（P?0.05）。伴/不伴肝性脑病两组患者，伴/不伴腹水两组患者，Child-Pugh B级与C级患者胆汁酸水平未提示有统计学差异（P?0.05）。结论 慢加急性肝衰竭患者粪便胆酸水平较正常人升高，但总胆汁酸和其他胆汁酸谱与正常对照相比没有发现显著差异。 |
| 关键词: 慢加急性肝衰竭,胆汁酸,高效液相色谱 |
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| 基金项目:广西医疗卫生适宜技术研究与开发项目(编号：S201313-04)；广西壮族自治区卫生厅医疗卫生科研课题(编号：Z2004002) |
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| A Research on the Change of Bile Acids Levels in Acute-on-chronic Liver Failure Patients |
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蒙丹丽1,2,3, 宋怀宇
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1.the people'2.'3.s Hospital of Guangxi Zhuang Autonomous region
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| Abstract: |
| Objective To study the change of fecal bile acids in patients with acute-on-chronic liver failure (ACLF). Method Twenty patients diagnosed with ACLF and fourteen healthy individuals were recruited. The levels of fecal Cholic acid, deoxycholic acid, chenodeoxycholic acid, ursodeoxycholic acid and total bile acids were meassured by high performance liquid chromatography technology (HPLC). Results 1. The level of fecal cholic acid in patients with chronic severe hepatitis B was higher than that in the control group (P < 0.05). The levels of cholic acid, deoxycholic acid, chenodeoxycholic acid, ursodeoxycholic acid and total bile acids in patients with chronic severe hepatitis B were not significantly different from those in the control group (P > 0.05) .2. The levels of SCFAs were compared each other when patients were divided into different groups by the characteristics of encephalopathy, ascites or hepatic reserve. There was no significant difference in all kinds of bile acids level between these two groups (P > 0.05) when divided by the aboved grouping conditions. Conclusion The levels of fecal cholic acid of ACLF patients was higher than that of healthy group, but it seem no difference in deoxycholic acid, chenodeoxycholic acid, ursodeoxycholic acid and total bile acids. |
| Key words: acute-on-chronic liver failure, bile acid, high efficiency liquid chromatography |
