| 摘要: |
| 目的 拟探讨急性心肌梗死(Acute Myocardial Infarction,AMI)患者经皮冠状动脉腔内支架植入术(Percutaneous Coronary artery Intervention,PCI)与认知功能的相关性。方法 本研究共纳入155例AMI患者,99例诊断AMI后行PCI治疗为PCI组,56例未行PCI治疗为对照组,所有对象入院后均使用认知功能电话问卷修订版(Telephone Interview for Cognitive Status-Modified,TICS-m)进行认知功能评估,相关生化指标均按广西壮族自治区人民医院检验科按标准流程进行检测。所有研究对象随访1年后再次进行认知功能评估。结果 两组之间基线TICS-m评分各项均无统计学差异(p>0.05),随访1年后再次进行认知功能评估,重复测量方差分析结果提示随着时间延长,对照组认知功能总分明显低于PCI组(31.07±1.74 vs. 32.56±2.21, p=0.000),其中对照组语言及注意力评分明显低于PCI组(13.16±1.43 vs. 14.49±1.64, p=0.000),但记忆力及定向力部分并未发现两组之间存在统计学差异(p>0.05)。对不同部位的AMI患者认知功能损伤进行分析发现,无论对照组还是PCI组,均未发现不同部位AMI患者随着时间延长认知功能损伤存在统计学差异(p>0.05)。结论 行PCI手术治疗的AMI患者远期认知功能损伤较未行PCI手术治疗者轻。 |
| 关键词: 急性心肌梗死 经皮冠状动脉腔内支架植入术(PCI) 认知功能损伤 |
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| 基金项目:广西医疗卫生适宜技术研究与开发项目(S2015 46)；广西壮族自治区卫生厅自筹经费科研课题(Z2014213)；国家自然科学基金(项目编号：81460061) |
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| The Relationship between PCI and Cognitive Impairment in AMI patients Shi Ying, Liu Hai-run, Yang Zi-cong, et al. Department of Cardiology, The People’s Hospital of Guangxi Zhuang Autonomous Region, Nanning, 530021, China |
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| Abstract: |
| Objective To investigate the relationship between PCI and cognitive function in AMI patients. Methods 155 AMI patients were enrolled in our study, 99 AMI cases that performed PCI were defined as PCI group, while 56 AMI cases who did not perform PCI were control group. Cognitive function was evaluated by TICS-m, Biochemistry indexes were test by standard program in the Lab of the People’s hospital of Guangxi Zhuang Autonomous Region. All subjects were follow up 1-year, medicine usage was recorded during follow-up, cognitive function was re-evaluated by TICS-m at the end of follow-up. Results There was no significant difference of TICS-m between PCI group and control group at baseline (p>0.05), the Repeated Measure ANOVA demonstrated that the total score of TICS-m was significant lower in control group than PCI group (31.07±1.743.77±1.78 vs. 32.56±2.214.61±1.81, p=0.000), further analyze found verbal and attention function scores were lower in control group than those in PCI group (13.16±1.431.80±1.26 vs. 14.49±1.642.71±1.47, p=0.000), while there was no significant difference of memory and orientation after 1-year follow up. Our results also did not find significant difference of cognitive function between different position of AMI in control group, as well as in PCI group (p>0.05). Conclusion There was more cognitive impairment in control group than in PCI group. |
| Key words: Acute Myocardial Infarction Percutaneous Coronary Artery Intervention Cognitive Impairment |
