| 引用本文: | 刘勇,刘艳丽,莫松柳,张利锋,赵洪磊▲.不同剂量阿托伐他汀对非ST段抬高型急性冠脉综合征效果比较[J].中国临床新医学,0,():-. |
| Liu yong,Liu yanli,Mo songliu,Zhang lifeng,Zhao honglei.不同剂量阿托伐他汀对非ST段抬高型急性冠脉综合征效果比较[J].中国临床新医学,0,():-. |
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| 不同剂量阿托伐他汀对非ST段抬高型急性冠脉综合征效果比较 |
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刘勇1,2,3,2,4,5,6,2,7,8, 刘艳丽1,2,3,2,4,5,6,2,7,8, 莫松柳1,2,3,2,4,5,6,2,7,8, 张利锋1,2,3,2,4,5,6,2,7,8, 赵洪磊▲1,2,3,2,4,5,6,2,7,8
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1.广东省东莞市桥头医院523538;2.<3.sub>4.sup>5.▲<6./sup>7./sub>8.中国医学科学院阜外医院深圳医院老年病科518020
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| 摘要: |
| 目的 探讨不同剂量阿托伐他汀治疗非ST段抬高型急性冠脉综合征患者的临床效果。方法 选取 2017-01—2019-12 间住院治疗的41 例非ST段抬高型急性冠脉综合征患者进行观察，按照随机数表法根据阿托伐他汀剂量不同将其分为治疗组( n=21)和对照组(n=20)，两组患者均予以常规治疗。治疗组在常规用药基础上加用20mg阿托伐他汀；对照组在常规治疗基础上第一天口服80mg 阿托伐他汀，后继续服用阿托伐他汀40mg/天，疗程均为6个月。比较两组患者治疗前后不同时间 TC、LDL－C、TG等指标改变情况及心血管事件发生情况。结果 治疗组与对照组治疗后2周、4周及24周血清TC、TG、LDL-C均明显低于治疗前，差异均有统计学意义(P<0.05)；对照组TC、LDL－C、TG水平在治疗2周及4周明显低于治疗组，差异均有统计学意义(P<0.05)。治疗组与对照组在治疗24周时TC、LDL－C、TG水平及心血管不良事件发生率比较差异无统计学意义(P＞0. 05)。结论阿托伐他汀(20mg/d)与阿托伐他汀(40mg/d)治疗非ST段抬高型急性冠脉综合征，在降低血脂及减少心血管不良事件的发生上有着相似的作用，值得临床推广应用。 |
| 关键词: 非ST段抬高型急性冠脉综合征 不同剂量 阿托伐他汀 临床效果 |
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| Effect of Different intensity of Atorvastatin on Patients with Non-ST segment elevation Acute Coronary Syndromes |
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Liu yong,Liu yanli,Mo songliu,Zhang lifeng,Zhao honglei
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QiaoTou Hospital of Dongguan,Department of Geriatrics,Shenzhen Hospital of Fuwai Hospital of Chinese Academy of Medical Sciences
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| Abstract: |
| Objective To investigate the clinical effect of different doses of atorvastatin in the treatment of Non-ST segment elevation Acute Coronary Syndromes(NSTE-ACS)．Methods A total of 41 patients with NSTE-ACS who were hospitalized in the hospital from January，2017 to December，2018 were divided into observation group(n=21) and control group (n=20). The two groups were both treated with conventional drugs. The observation group was treated with 20mg atorvastatin and the control group was treated with 80mg atorvastatin on first day, 40mg atorvastatin subsequently. There were six months of treatment in both groups. Before treatment, and 2 weeks, 4 weeks and 24 weeks after treatment, the levels of blood lipid and the occurrences of major cardiovascular events were assayed in the two groups. Results The levels of serum TC, LDL-C, TG in two groups after treating 2 weeks, 4 weeks and 24 weeks were significantly lower than before treatment, and the differences were statistically significant (P<0.05). 2 weeks and 4 weeks after treatment, the levels of serum TC, LDL-C, TG in control group was significantly lower than observation group, with statistically significant differences (P<0.05). After treating 24 weeks the levels of serum TC, LDL-C, TG and occurrence of the main adverse cardiovascular events have no significantly differences in two groups (P<0.05).
Conclusion Moderate intensity atorvastatin (20mg/d) is similar to high intensity atorvastatin (40mg/d) on reducing the blood lipid level and the occurrence of cardiovascular adverse events in NSTE-ACS patients. |
| Key words: Non-ST segment elevation Acute Coronary Syndromes Different intensity Atorvastatin Clinical effect |
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