| 摘要: |
| 目的 观察支气管舒张试验的不良反应并探讨其安全性。方法 采用问卷调查方式对1109例行支气管舒张试验的受试者进行不良反应评价，主要包括一般临床资料、不良反应的症状及其程度、处理措施、恢复情况及是否空腹等。结果 132例（11.9%）受试者发生155个不良反应，其中21例同时发生2～3个不良反应。不良反应以神经肌肉症状发生率最高，其次为心血管症状，其中双手震颤47例，心动过速36例，发生率分别为4.2%、3.2%。空腹组出现不良反应的发生率较非空腹组高，其中双手震颤与心动过速在两组间差异均有统计学意义（?2 = 8.950，P = 0.003；?2 = 5.527，P = 0.019）。轻度和中度不良反应分别占83.9%和16.1%，无重度不良反应。结论 支气管舒张试验可引起不良反应，但大多是为轻度不良反应，支气管舒张试验是安全的。 |
| 关键词: 支气管舒张试验 沙丁胺醇 不良反应 |
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| Adverse Reactions and Safety Analysis of Bronchial Dilation Test |
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Northern Jiangsu Province Hospital
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| Abstract: |
| Objective To investigate the adverse reactions and safety in subjects who receive bronchial dilation test. Methods 1109 subjects who underwent bronchial dilation test were assessed by questionnaire survey of adverse reactions. The contents of survey mainly included the demographic characteristics, the symptoms and degrees of adverse reactions, treatment, recovery and whether on an empty stomach in all subjects. Results A total of 155 adverse reactions were recorded in 132 subjects (11.9%), of whom 21 patients experienced two or three adverse reactions. The incidence rate of adverse reactions was ordered as neuromyic symptoms and cardiovascular symptoms, with tremor (47, 4.2%) and tachycardia (36, 3.2%) being the most common. The subjects with an empty stomach showed significantly higher incidence rate of tremor (?2 = 8.950，P = 0.003) and tachycardia (?2 = 5.527，P = 0.019) compared to the patients without an empty stomach. Of all adverse reactions, 83.9% were mild, 16.1% were moderate and no severe adverse reaction was recorded. Conclusion Bronchial dilation test may cause certain adverse reactions, but the majority of them are mild, so the measurement remains safe. |
| Key words: Bronchial dilation test Salbutamol Adverse reactions |
