| 摘要: |
| 目 的 采用不同剂量的铁氰化锰纳米对比剂对大鼠肝脏进行磁共振增强扫描,分析肝脏强化程度与对比剂注射剂量的关系,探讨铁氰化锰纳米对比剂对大鼠肝脏增强效果的最佳注射剂量。方 法 将健康雄性SD大鼠随机分为6组,每组6只,经尾静脉注射不同剂量的铁氰化锰纳米对比剂,剂量分别为20 μmol/kg、25 μmol/kg、30 μmol/kg、50 μmol/kg、80 μmol/kg、150 μmol/kg体重。注射前、后分别对大鼠肝脏进行T1WI(TR=100 ms,TE=7.6 ms)序列扫描,采用单因素方差分析比较不同剂量对比剂增强后肝脏SNR,两两比较采用LSD法。结 果 20 μmol/kg、25 μmol/kg、30 μmol/kg、50 μmol/kg体重注射剂量增强后肝脏SNR依次升高,50 μmol/kg达到高峰,80 μmol/kg、150 μmol/kg体重注射剂量增强后肝脏SNR下降。结 论 铁氰化锰纳米对比剂50 μmol/kg体重注射剂量时肝脏SNR最高,为肝脏增强效果最佳的注射剂量。 |
| 关键词: 磁共振成像 对比剂 锰 纳米 注射剂量 |
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| Comparison of enhancement effect in the rat liver with different doses of manganese hexacyanoferrate nanoparticles contrast agentPan Dongmei,Fan Guohua |
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潘冬梅
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Jining No. 1 People’s Hospital
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| Abstract: |
| Objective To investigate the best injecting dose for enhancement effect in the liver by performing magnetic resonance enhanced scan for rat liver using different injection doses of manganese hexacyanoferrate nanoparticles, then analyzing the relationships between injection dose and the degree of enhancement in the liver. Methods Healthy male SD rats were randomly divided into 6 groups, each group with 6 rats. Different doses of manganese hexacyanoferrate nanoparticles contrast agent were injected via a vein of tail. The doses were 20 μmol/kg, 25 μmol/kg, 30 μmol/kg, 50 μmol/kg, 80 μmol/kg and 150 μmol/kg respectively. Liver of rat was scanned with T1WI (TR=100 ms, TE=7.6 ms) sequence before and after injection respectively. SNR were compared between different doses after enhancement using one-way analysis of variance. LSD method was used in pair wise comparison. Results SNR of liver increased orderly with doses of 20 μmol/kg, 25 μmol/kg, 30 μmol/kg and 50 μmol/kg. SNR reached highest at the dose of 50 μmol/kg, while they decreased at dose of 80 μmol/kg and 150 μmol/kg. Conclusions SNR of liver reached highest at dose of 50 μmol/kg, which was the best injecting dose for enhancement effect in liver. |
| Key words: Magnetic resonance imaging Contrast agent Manganese Nanometer Injection dose |
