引用本文: | 李静玲,韦海明,赵仁峰,凌丹,郑满足.Versican在子宫内膜样腺癌中的表达及其与血清CA125水平的关系[J].中国临床新医学,0,():-. |
| 李静玲.Versican在子宫内膜样腺癌中的表达及其与血清CA125水平的关系[J].中国临床新医学,0,():-. |
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摘要: |
目的: 观察多功能蛋白聚糖(Versican)和血清CA125水平在子宫内膜样腺癌中的表达,探讨其与子宫内膜样腺癌临床病理学特征的关系。方法: 免疫组织化学方法检测Versican的在子宫内膜样腺癌(60例)、不典型子宫内膜增生(40例)和正常子宫内膜组织(20例)中表达;用化学发光免疫分析法检测患者血清CA125水平。结果: Versican 在子宫内膜样腺癌、不典型子宫内膜增生和正常子宫内膜组织中阳性率分别为75.0%、57.5% 和5.0%;血清CA125水平在子宫内膜样腺癌、不典型子宫内膜增生和正常子宫内膜组织中阳性率分别为33.3%、7.5% 和0%; Versican的表达分别在子宫内膜样腺癌和不典型子宫内膜增生中均高于正常子宫内膜组织,差异有统计学意义(P < 0.05)。在子宫内膜样腺癌中,血清CA125水平均高于正常子宫内膜组织和不典型子宫内膜增生(P < 0.05), Versican与血清CA125呈正相关(r=0.301,P=0.016)。结论: 应用血清CA 125和免疫组织化学标记物Versican为临床医生早期诊断子宫内膜样癌提供了有价值的指导。 |
关键词: 血清CA125 Versican 子宫内膜样腺癌 免疫组化 |
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基金项目:广西医疗卫生适宜技术开发与推广应用项目(S2017086) |
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The Expression of Vercican in Endometrial Carcinoma and Its Relationship Serum CA125 Level |
李静玲
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the People''s Hospital of Guangxi Zhuang Autonomous Region,Nanning 530021,China
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Abstract: |
Objective:To observed the expressions of versicanand serum CA125levels in endometrial carcinoma,and to investigate their relations with the clinicopathological features of endometrial carcinoma. Methods:Endometrial carcinomas (n=60), atypical endometrial hyperplasia (n=40) and normal endometrial tissue(n=20) were collected. Immunohistochemistrical methods were used to detect the expression ofversican.The Serum CA125levels in patients weredetected by Chemiluminescence Immunoassay.Results:The postive rates of versican in the endometrial carcinomas , atypical endometrial hyperplasia and normal endometrial tissue were 75.0%、57.5% and 5.0%,respctively, The postive rates of serum CA125levels in the endometrial carcinomas, atypical endometrial hyperplasia and normal |
Key words: serum CA125 versican endometrial carcinoma immunohistochemical |