摘要: |
目的 对潮州地区0-3岁婴幼儿血清维生素A(VA)和维生素D(VD)营养状况进行调查,评估VA和VD缺乏和不足对发生呼吸道感染和血常规白细胞计数、血小板(PLT)、平均血小板体积(MPV)的影响。方法 683例潮州地区0-3岁常住儿童纳入研究,收集临床资料,检测血清VA、VD水平和血常规,计算体质指数Z分值(BMI-Z分值)。结果 0-3岁婴幼儿VA和VD水平分别为(325.43±199.62)μg/L、(27.38±9.84)ng/mL。VA缺乏和不足发生率分别为5.27%和30.31%;VD 缺乏和不足发生率分别为23.43%和28.55%。<1岁组VA水平低于1-3岁组,但其VD水平、VA不足发生率、VD缺乏及不足的发生率均高于1-3岁组。BMI-Z<1组VA 、VD水平均低于BMI-Z≥1组,BMI-Z<1组VA和VD不足发生率高。母乳喂养>6个月与<6个月者相比,两组婴儿VA和VD水平、VA缺乏和不足的发生率相当;母乳喂养>6个月者VD缺乏和不足的发生率均低于喂养<6个月者。VD缺乏和不足婴幼儿的呼吸道感染发生次数高于VD正常者。VA缺乏者PLT比VA正常组少,VD缺乏和不足儿童MPV比VD正常组儿童高。结论 潮州地区0-3岁婴幼儿VA和VD缺乏及不足的发生率高,营养状况不佳与母乳喂养时间短是VA、VD缺乏及不足的危险因素,呼吸道感染发生次数增多与VD缺乏及不足有关;VA、VD缺乏和不足可能通过影响血小板功能使免疫功能下降。 |
关键词: 维生素A 维生素D 婴幼儿 呼吸道感染 白细胞 血小板 |
DOI: |
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基金项目:广东省潮州市科技计划项目(编号:2015GY43) |
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Assessment of the nutritional status of vitamin A and D in infants aged 0-3 years in Chaozhou |
谢维波
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Second People''s Hospital of Chaoan
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Abstract: |
Objective To investigate the status of vitamin A (VA) and vitamin D (VD) in infants aged 0-3y in Chaozhou, evaluate the effects of VA and VD deficiency or insufficiency on incident rate of respiratory infection, leucocyte counts, platelet (PLT) count and mean platelet volume (MPV) in these infants. Methods 683 infants who lived in Chaozhou were enrolled. Clinical data were recorded. Serum VA, VD, and blood routine examination were detected by routine methods. Body masses index (BMI) Z score was calculated. Results VA and VD level of infants aged 0-3y was (325.43±199.62) μg/L, (27.38±9.84) ng/mL, respectively. 5.27% and 30.31% infants were found to be VA deficient or insufficient, and, 23.43% and 28.55% infants were VD deficient or insufficient. VA level in <1y infants was lower than that in 1-3y infants, and the percentage of VA or VD deficiency or insufficiency in <1y infants was higher than that in 1-3y infants. Infants with BMI-Z <1 had lower levels of VA and VD, and higher percentage VA and VD deficiency or insufficiency than those with BMI-Z ≥1. In <1y infants, those with breast feeding < 6 months were found to be higher percentage of VA insufficiency and VD deficiency or insufficiency than those > 6 months. High frequency of respiratory infection was found in infants with VD deficiency or insufficiency. PLT count in infants with VA deficiency was less than that in those with normal VA level, and MPV in infants with VD deficiency or insufficiency was bigger than that in infants with normal VD level. Conclusions Our results showed a high prevalence of VA and D deficiency or insufficiency in children aged 0-3y in Chaozhou, and risk factors included low BMI and breast feeding < 6 months. VD deficiency or insufficiency may be risk factor of respiratory infection. Low levels of VA and VD may lead to immunome promise by decreasing PLT count and increasing MPV. |
Key words: vitamin A vitamin D infant respiratory infection leukocyte platelet |