引用本文:陆江玉,李镇杰,石凤,蒋玉洁,黄霞,韦凌云,农进,陈红.广西壮族人群TLR2基因rs2289318G/C和rs3804100T/C的多态性研究[J].中国临床新医学,0,():-.
lujiangyu.广西壮族人群TLR2基因rs2289318G/C和rs3804100T/C的多态性研究[J].中国临床新医学,0,():-.
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广西壮族人群TLR2基因rs2289318G/C和rs3804100T/C的多态性研究
陆江玉1, 李镇杰1, 石凤2, 蒋玉洁1, 黄霞1, 韦凌云1, 农进1, 陈红1
1.右江民族医学院附属医院;2.右江民族医学院
摘要:
目的 探讨广西壮族人群Toll样受体2(TLR2)基因rs2289318G/C和 rs3804100T/C多态性，比较其与不同地区及种族的分布差异。方法 采用单碱基延伸技术和DNA测序法对210例广西壮族健康体检者TLR2基因rs2289318G/C和rs3804100T/C进行基因分型，分析其基因多态性，并与千人基因组计划数据库公布的ASW、ACB、YRI、AMR、JPT、EUR、SAS和CHB人群进行比较。结果 rs2289318G/C存在GG、CG、CC基因型和G、C等位基因，频率分别为58.57%、37.62%、3.81%、77.38%、22.62%。rs3804100T/C存在TT、CT、CC基因型和T、C等位基因，频率分别为57.62%、38.10%、4.29%、76.67%、23.33%。rs2289318G/C和 rs3804100T/C基因型及等位基因在不同性别间的分布频率差异无统计学意义(P>0.05)。广西壮族人群rs2289318G/C等位基因与SAS比较差异有统计学意义( P<0.05)，但基因型和等位基因频率与ACB、ASW、YRI、AMR、JPT、EUR、CHB比较差异无统计学意义(P>0.05)。rs3804100T/C的基因型及等位基因频率与ACB、ASW、YRI、AMR、EUR、SAS、CHB比较差异有统计学意义( P<0.05)，rs3804100T/C基因型频率及等位基因频率与JPT比较，差异无统计学意义(P>0.05)。结论 广西壮族人群TLR2基因rs2289318G/C、rs3804100T/C多态性与不同种族人群比较存在差异。
关键词:  TLR2基因；多态性；广西壮族人群  种族。
DOI：
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基金项目:国家自然科学基金资助项目（81860021）；百色市自筹课题（百科20202508）
TLR2 gene rs2289318G/C and rs3804100T/C polymorphism in Guangxi Zhuang Population distribution
lujiangyu
Affiliated Hospital of Youjiang Medical College
Abstract:
Objective To investigate the rs2289318G/C and rs3804100T/C polymorphisms of Toll-like receptor 2 (TLR2) genes in Guangxi Zhuang population, and compare their distributions with different regions and races. Methods Single extension technique and DNA sequencing were used to detect the genotype of rs2289318G/C and rs3804100T/C of TLR2 gene in 210 healthy subjects among Guangxi Zhuang population. The genetic polymorphisms were analyzed and compared with ASW, ACB, YRI, AMR, JPT, EUR, SAS and CHB population published by Thousand Human Genome Project database. Results There were GG, CG, CC genotypes and G, C alleles in rs2289318G/C, and the frequencies were 58.57%, 37.62%, 3.81%, 77.38% and 22.62%, respectively. There were TT, CT, CC genotypes and T, C alleles in rs3804100T/C, and the frequencies were 57.62%, 38.10%, 4.29%, 76.67% and 23.33% respectively. There was no statistically significant difference in genotype and allele frequencies between rs2289318G/C and rs3804100T/C in different genders (P>0.05). There was statistically significant difference in rs2289318G/C allele between Guangxi Zhuang population and SAS (P<0.05), but there was no statistically significant difference in genotype and allele frequencies while comparing with those of ACB, ASW, YRI, AMR, JPT, EUR and CHB (P<0.05). The genotype and allele frequencies of rs3804100T/C in Guangxi Zhuang population were significantly different from those of ACB, ASW, YRI, AMR, EUR, SAS and CHB (P<0.05). However, there was no statistically significant difference in rs3804100T/C genotype frequencies and allele frequencies between Guangxi Zhuang population and JPT(P>0.05). Conclusion The TLR2 gene rs2289318G/C and rs3804100T/C polymorphism in Guangxi Zhuang population is different from other ethnics.
Key words:  TLR2 genes  polymorphism  Guangxi Zhuang population  ethnics.