| 引用本文: | 陈其桂,成俊萍,薛林涛,谭卫红,李金燕,何泳志,黄泰帅.不同不育类型患者精液质量比较及对R-ICSI结局的影响[J].中国临床新医学,0,():-. |
| chenqigui,chengjunping,xuelintao,tanweihong,lijinyan,heyongzhi,huangtaishuai.不同不育类型患者精液质量比较及对R-ICSI结局的影响[J].中国临床新医学,0,():-. |
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| 摘要: |
| 目的 探讨不同不育类型患者精液质量情况及其对补救卵胞浆内单精子注射术（R-ICSI）结局的影响。 方法 回顾性分析2014年1月至2018年12月期间在广西壮族自治区人民医院生殖医学与遗传中心行常规体外受精-胚胎移植（IVF-ET）失败需行R-ICSI的98对不育夫妇的临床资料，根据不育类型分为原发性不育组（n=56）与继发性不育组（n=42），比较两组患者的一般情况、精液质量、胚胎发育情况及临床结局。 结果 （1）原发性不育组女方年龄较继发性不育组小（P＜0.05），原发性不育组获卵数较继发性不育组多（P＜0.05），余一般情况指标比较无显著差异（P＞0.05）。（2）继发性不育组前向运动精子百分率优于原发性不育组（P＜0.05），原发性不育组精子DNA断裂指数（DFI）高于继发性不育组（P＜0.05），余精液质量指标比较无显著差异（P＞0.05）。（3）原发性不育组临床妊娠率高于继发性不育组，两组比较差异有统计学意义（57.50%vs29.03%，P＜0.05）。另外，两组患者受精率、卵裂率、优胚率、活产率、早产率、流产率、单胎率及双胎率均无显著差异（P＞0.05）。 结论 原发性不育患者精液质量较差，但女方年龄小，获卵数多，有利于临床妊娠，在行生殖助孕诊疗时，需把不育类型列入考虑范畴。 |
| 关键词: 原发性不育 继发性不育 精液质量 补救卵胞浆内单精子注射术 结局 |
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| 基金项目:国家自然科学基金（81360107）；广西自然科学基金（2019GXNSFAA185056）；广西卫健委科研课题（Z20170376） |
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| Comparison of semen quality in patients with different types of infertility and its effect on the outcome of rescue ICSI |
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chenqigui,chengjunping,xuelintao,tanweihong,lijinyan,heyongzhi,huangtaishuai
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THE PEOPLE''S HOSPITAL OF GUANGXI ZHUANG AUTONOMOUS REGION
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| Abstract: |
| Objective：To investigate the semen quality of patients with different types of infertility and its effect on the outcome of rescue ICSI.
Methods：This retrospective analysis was conducted among 98 infertile couples receiving rescue intracytoplasmic sperm injection due to failure of in vitro fertilization procedures in the Reproductive Medicine and Genetics Center of the people's Hospital of Guangxi Zhuang Autonomous region from January 2014 to December 2018.According to different infertilitytypes, the patients were divided into primary infertility group (n=56) and secondary infertility group (n=42). The general clinical data, semen quality, embryo development and clinical outcome of the two groups were compared.
Results：(1)The female age in the primary infertility group was younger than that in the secondary infertility group (P<0.05). The eggs in the primary infertility group was more than that in the secondary infertility group (P<0.05), but there was no significant difference in other general clinical data (P>0.05). (2) The sperm progressive motility in the secondary infertility group was higher than that in the primary infertility group(P<0.05). The sperm DNA fragmentation index ((DFI)) in the primary infertility group was higher than that in the secondary infertility group (P<0.05). There was no significant difference in othersemen quality(P>0.05). (3)The clinical pregnancy rate in the primary infertility group was higher than that in the secondary infertility group, and there was significant difference between the two groups (57.50% vs 29.03%, P<0.05). In addition, there was no significant difference in the fertilization rate, cleavage rate, good embryo rate, live birth rate, premature delivery rate, abortion rate, single fetus rate and twin fetus rate between the two groups (P>0.05).
Conclusion：The semen quality of patients with primary infertility is poor, but the wife is younger and has more eggs, which is beneficial to clinical pregnancy,suggesting that the infertility types should be considered in the diagnosis and treatment process. |
| Key words: primary infertility secondary infertility semen quality rescue intracytoplasmic sperm injection outcome |
