| 摘要: |
| 目的 探讨甘油三酯葡萄糖指数（Triglyceride-glucose index，TyG指数）控制水平与冠心病患者经皮冠状动脉介入治疗后支架内再狭窄（In-stent restenosis,ISR）的相关性。方法 选取冠心病行PCI治疗患者，并于术后6～12个月完成冠状动脉造影随访的患者共243例，根据冠状动脉造影结果分为再狭窄组（n=45）和非再狭窄组（n=198）。比较两组患者的一般临床资料、冠状动脉造影结果、首次PCI术前和复查造影时的实验室指标。应用ROC曲线分析得到TyG指数对PCI术后发生支架内再狭窄的预测临界值9.04，AUC为0.742（95%CI：0.678～0.806，P<0.001），敏感度为87%，特异度为60%。使用Logistic回归分析冠心病患者发生支架内再狭窄的预测因子。结果 首次PCI术前再狭窄组的TyG指数明显高于非再狭窄组（9.45±0.40 VS 9.00±0.71,P<0.001）；复查造影时再狭窄组的TyG指数明显高于非再狭窄组（9.30±0.31 VS 8.66±0.81,P<0.001）；多因素Logistic回归分析结果表明吸烟（OR:6.172,95%CI：2.609～14.599；P<0.001）、合并糖尿病（OR:3.323,95%CI：1.442～7.658；P=0.005）、TyG指数未达标（OR:5.331,95%CI：1.838～15.463；P=0.002）是冠心病患者发生ISR的独立危险因素。结论 TyG指数有可能作为冠心病患者PCI术后支架内再狭窄的一项独立预测指标,控制冠心病患者PCI术后的TyG指数水平可能减少支架内再狭窄的发生。 |
| 关键词: 经皮冠状动脉介入治疗 支架内再狭窄 甘油三酯葡萄糖指数 |
| DOI： |
| 分类号: |
| 基金项目: |
|
| The correlation between triglyceride-glucose index control and in-stent restenosis of the coronary artery |
|
|
|
昆明医科大学第二附属医院
|
| Abstract: |
| Objective To investigate the association of triglyceride-glucose(TyG) index control and in-stent restenosis(ISR) in patients with coronary heart disease after percutaneous coronary intervention(PCI).Methods A total of 243 patients with coronary heart disease who underwent PCI and underwent follow-up angiography ranging from 6 to 12 months after PCI were selected,according to the results of coronary angiography, they were divided into in-stent restenosis group (n=45) and non in-stent restenosis group (n=198).The general clinical data,coronary angiography results,laboratory indexes before the first PCI and during the reexamination of angiography were compared between the two groups.ROC curve was used to analyze the predictive critical value of TyG index for in-stent restenosis after PCI was 9.04, AUC was 0.742 (95%CI: 0.678 ~ 0.806, P<0.001), sensitivity was 87%, specificity was 60%.Logistic regression was used to analyze the predictors of in-stent restenosis in patients with coronary heart disease.Results Before the first PCI, the TyG index of ISR group was significantly higher than non-ISR group (9.45±0.40 VS 9.00±0.71,P<0.001)；during the reexamination of angiography,TyG index of theISR group was significantly higher than non-ISR group (9.30±0.31 VS 8.66±0.81,P<0.001). Multivariate logistic regression analysis showed that smoking (OR:6.172,95%CI: 2.609-14.599; P<0.001), diabetes mellitus (OR:3.323,95%CI: 1.442-7.658; P=0.005)and TyG index was not up to standard (OR:5.331,95%CI: 1.838-15.463; P=0.002) were the independent risk factor for ISR in patients with coronary heart disease.Conclusion TyG index may be an independent predictor of in-stent restenosis in patients with coronary heart disease after PCI,controlling TyG index level of patients after PCI may reduce the occurrence of in-stent restenosis. |
| Key words: Percutaneous coronary intervention In-stent restenosis Triglyceride-glucose index |
