| 引用本文: | 方坚,阮梅,夏磊,黄倩,陈丰穗,张志强,张霞,赖彦华,李懿,吴志贤,周丽丽.着丝粒蛋白L表达与肝移植术后肝癌复发的关系临床研究[J].中国临床新医学,0,():-. |
| fangjian,ruanmei,xialei,huangqian,zhoulili.着丝粒蛋白L表达与肝移植术后肝癌复发的关系临床研究[J].中国临床新医学,0,():-. |
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| 着丝粒蛋白L表达与肝移植术后肝癌复发的关系临床研究 |
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方坚1, 阮梅1, 夏磊1, 黄倩1, 陈丰穗2, 张志强2, 张霞2, 赖彦华3, 李懿4, 吴志贤2, 周丽丽2
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1.福建中医药大学附属第三人民医院;2.联勤保障部队第900医院;3.广西自治区人民医院;4.联勤保障部队第920医院
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| 摘要: |
| 目的：研究着丝粒蛋白L(CENPL)在肝移植术后肝癌复发中的临床价值。方法：筛选肝移植术后肝癌复发的患者93例(REC组),选择同期手术且性别、年龄匹配的未复发患者46例作为对照组(CON组)。对肝移植手术标本进行免疫组化染色,观察CENPL表达情况,与患者临床病理参数包括人口学资料、移植参数等进行相关性分析,采用COX回归模型分析复发患者的危险因素,并采用生存曲线分析CENPL表达在患者无复发生存(RFS)中的价值。结果： REC组68.8%的患者高表达CENPL,而CON组高表达的比例为41.3%,差异有统计学显著意义(p=0.0019)。COX回归模型显示CENPL表达(p=0.0032)及CNLC分期(p=0.013)是复发的独立危险因素。Kaplan-Meier生存曲线分析显示,CENPL高表达组RFS显示短于低表达组(Log-rank test, p=0.0023；Gehan-Breslow-Wilcoxon test, p=0.0002)。结论：CENPL是肝移植术后患者肝癌复发的生物标志物,检测其表达对预测复发有重要参考价值。 |
| 关键词: CENPL 肝癌 肝移植 肿瘤复发 |
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| 基金项目:福建省自然科学基金项目(面上) （2020J011131）；福建省科技创新联合资金项目（2019Y9044） |
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| Clinical study on the relationship between the expression of centromere protein L and the recurrence of hepatocellular carcinoma after liver transplantation |
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fangjian,ruanmei,xialei,huangqian,zhoulili
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1.The Third Affiliated People'2.'3.s Hospital of Fujian University of Traditional Chinese Medicine
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| Abstract: |
| Objective: To study the clinical value of centromere protein L (CENPL) in the recurrence of hepatocellular carcinoma after liver transplantation. Methods: A total of 93 patients with liver cancer recurrence after liver transplantation were selected (REC group), and 46 non-recurrence patients who underwent simultaneous surgery and were matched for gender and age were selected as the control group (CON group). Immunohistochemical staining was performed on liver transplantation specimens to observe the expression of CENPL, and the correlation analysis with the clinicopathological parameters of patients, including demographic data, transplantation parameters, etc., was used to analyze the risk factors of recurrence patients and survival curve analysis. The value of CENPL expression in recurrence-free survival (RFS) of patients. Results: 68.8% of patients in REC group had high expression of CENPL, while the proportion of high expression in CON group was 41.3%, and the difference was statistically significant (p=0.0019). COX regression model showed that CENPL expression (p=0.0032) and CNLC stage (p=0.013) were independent risk factors for recurrence. Kaplan-Meier survival curve analysis showed that the CENPL high expression group showed shorter RFS than the low expression group (Log-rank test, p=0.0023; Gehan-Breslow-Wilcoxon test, p=0.0002). Conclusion: CENPL is a biomarker for the recurrence of liver cancer in patients after liver transplantation, and the detection of its expression has important reference value for predicting recurrence. |
| Key words: CENPL liver cancer liver transplantation tumor recurrence |
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