| 摘要: |
| ［摘要］ 目的 探讨苦参素与聚肌胞联合治疗慢性乙型肝炎、肝硬化的疗效。方法 随机抽取129例HBV-DNA（+）、肝功能异常的慢性乙肝病患者，采用苦参素注射液联合聚肌胞肌注，配合保肝治疗；定期观察肝功能、HBV-DNA、肝胆B超，一般治疗1～2疗程（3～6个月），停药后观察1年以上。结果 治疗1疗程肝功能恢复正常者89.1%；HBV-DNA未转阴者继续治疗，治疗结束时HBV-DNA转阴率61.2%，停药1年内血清HBV-DNA复阳率35.4%，肝功能异常复发率40.8%；复阳后重新治疗仍然有效，血清HBV-DNA再次转阴率68.7%。结论 以苦参素联合聚肌胞为主，配合保肝降酶治疗，抗HBV的近期疗效确切，伴随疗程的延长，HBV-DNA转阴率增加，但是停药后有复发现象，重新用药依然有效。 |
| 关键词: 苦参素 聚肌胞 抗HBV 疗效 |
| DOI：10.3969/j.issn.1674-3806.2009.07.22 |
| 分类号:R 512.6 |
| 基金项目: |
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| Observation on therapeutic efficacy of kushenin and polyinosinicacid-polycytidylic acid in the treatment of chronic hepatitis B and hepatic cirrhosis |
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LU Yi-min
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Rushan Hospital of Traditional Chinese Medicine, Rushan Shandong 264500, China
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| Abstract: |
| ［Abstract］ Objective To investigate the therapeutic efficacy of kushenin and polyinosinicacid-polycytidylic acid in the treatment of chronic hepatitis B and hepatic cirrhosis.Methods One hundred and twenty-nine chronic hepatitis B patients or hepatis cirrhosis patients with positive HBV-DNA, and abnormal liver function were randomly selected, and were treated by intra-muscular injection of kushenin and polyinosinicacid-polycytidylic acid，combined with liver-protecting treatment.The regular observation of liver function, HBV-DNA, hepatobiliary B-ultrasound examination were performed. The patients were observed for over one year after drug withdrawal.Results The clinical efficiency rates whose liver function was recovered to the normal level after 1 course of treatment was 89.1%. the HBV-DNA negative conversion rate at the end of treatment was 61.2%. For the patients with positive conversion of HBV-DNA during one year withdrawal poriod, the retreatment was still effective.Conclusion Kushenin and polyinosinicacid-polycytidylic acid combined with liver-protecting and enzyme reducing treatment has obvious short-term efficacy on anti-HBV. With treatment prolonged, HBV-DNA negative conversion rate will increase and recurrence was observed in withdrawal period, however the retreatment will be still effective. |
| Key words: Kushenin(oxymatrinae) Polyinosinicacid-polycytidylic acid Anti- HBV Therapeutic efficacy |
