| 摘要: |
| ［摘要］ 目的 探讨甲钴胺治疗化疗后周围神经毒性的疗效。方法 将2006-11～2008-11 76例化疗后出现周围神经病变的患者随机分成两组。其中治疗组38例，予以甲钴胺500 μg，肌肉注射治疗，1次/d；对照组38例，予维生素B12 500 μg，肌肉注射治疗，1次/d。疗程均为半个月。结果 治疗组有效率92.1%，对照组有效率34.2%，两组疗效比较差异有统计学意义(P<0.01)。结论 甲钴胺可以明显改善化疗后的周围神经病变。 |
| 关键词: 甲钴胺 化疗 神经毒性 |
| DOI：10.3969/j.issn.1674-3806.2009.08.25 |
| 分类号:R 730.53 |
| 基金项目: |
|
| Clinical investigation on efficacy of mecobalamine in treating patients with chemotherapy-induced peripheral neuropathy |
|
OU Mei, YE Dong-mei
|
|
Department of Oncology, the People′s Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021, China
|
| Abstract: |
| ［Abstract］ Objective To investigate the efficacy of mecobalamine in treating patients with chemotherapy-induced peripheral neuropathy.Methods Between November 2006 and November 2008, 76 cancer patients with chemotherapy-induced peripheral neuropathy were randomly assigned into the study group and the control groop. Thirty-eight patients in the study groop received intramuscular injection of mecobalamine in a dose of 500 μg, once daily， whereas thirty-eight patients in the control groop received intramuscular injection of vitamin B12 in a dose of 500 μg, once daily，the treatment duration for both groop was fifteen days.Results A significantly higher overall response rate was found in the study groop compared with those in the control groop (92.1% versus 34.2%, P<0.01).Conclusion Mecobalamine is effective in treating chemotherapy-induced peripheral neuropathy. |
| Key words: Mecobalamine Chemotherapy Neurotoxicity |
