| 摘要: |
| ［摘要］ 目的 观察不同剂量辛伐他汀对缺血性脑血管病患者颈动脉内膜中层厚度的影响及用药安全性。方法 186例缺血性脑血管病人随机分为辛伐他汀10 mg/d、20 mg/d、30 mg/d及40 mg/d治疗组, 分别测定随访6个月前后的颈动脉内膜中层厚度，比较组内和组间的差异性以及组间用药后不良反应。结果 6个月后，各组与治疗前颈动脉内膜中层厚度比较（P<0.05），10 mg/d组与其它三组颈动脉内膜中层厚度比较（P<0.05），20 mg/d组与30 mg/d组颈动脉内膜中层厚度比较（P>0.05），20 mg/d组与40 mg/d组颈动脉内膜中层厚度比较（P<0.05）；10 mg/d组与20 mg/d组不良反应比较（P>0.05）, 10 mg/d组、20 mg/d组与另两组比较（P<0.05）。结论 四组剂量的辛伐他汀治疗均能降低颈动脉内膜中层厚度，但20 mg/d组既能有效地降低颈动脉内膜中层厚度，又能避免高不良反应率。 |
| 关键词: 辛伐他汀 颈动脉内膜中层厚度 用药安全性 |
| DOI：10.3969/j.issn.1674-3806.2009.09.06 |
| 分类号:R 743 |
| 基金项目: |
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| The effect of different dose simvastatin on carotid intimamedia thickness of ischemic cerebrovascular disease patients and study on safety of medication |
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HONG Xing
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Department of neurology, the Second Affiliated Hospital of Wannan Medical College, Wuhu 241000, China
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| Abstract: |
| ［Abstract］ Objective To observe the effect of different dose simvastatin on carotid intimamedia thickness(IMT) of ischemic cerebrovascular disease patients and the safety of medication.Methods One hundred and eighty-six ischemic cerebrovascular disease patients were randomly divided into 10 mg/d、20 mg/d、30 mg/d、40 mg/d four simvastastin treatment group. All patients were examined the carotid intimamedia thickness before treatment and after six months treatment, then compared the variability of the carotid IMT within group and between groups, and compared untoward reaction of medication between groups.Results After 6 months treatment, every comparisions and corresponding t-values were as follows: the carotid IMT of every group compared with before treatment, P<0.05； the carotid IMT of 10mg/d group compared with other three groups, P<0.05; the carotid IMT of 20 mg/d group compared with 30 mg/d group, P>0.05；the carotid IMT of 20mg/d group compared with 40 mg/d group, P<0.05；the rate of untoward reaction of 10 mg/d group compared with 20 mg/d group, P>0.05; the rate of untoward reaction of 10mg/d group and 20mg/d group compared with other two groups, P<0.05.Conclusion Four groups simvastatin treatment can degrade carotid IMT, 20mg/d group can degrade carotid IMT effectually, but also avoid high rate of untoward reaction of medication. |
| Key words: Simvastatin Intimamedia thickness(IMT) Safety of medication |
