| 摘要: |
| ［摘要］ 目的 研究黄芪与抗生素联合应用对福氏痢疾杆菌感染后大鼠肠功能的影响，为治疗肠道感染后所致的肠道感觉运动功能紊乱提供指导。方法 将40只雄性Wistar大鼠分为正常对照组、模型组、抗生素治疗组、黄芪与抗生素联合治疗组4组（每组10只）。大鼠成功造模后，分别给予相应药物。在感染后15～20d，所有大鼠进行直肠气囊扩张，测定肠道感觉阈值。结果 模型组和抗生素治疗组的肠道感觉阈值较正常组明显降低（P<0.05），联合治疗组肠道感觉阈值与正常组比较差异无统计显著意义。结论 大鼠在福氏痢疾杆菌感染炎症消失后存在着肠功能紊乱，单纯应用抗生素治疗无法使肠道的感觉运动功能恢复正常，黄芪与抗生素联合应用可以使肠道感觉运动功能恢复正常。 |
| 关键词: 感染 肠功能紊乱 黄芪 抗生素 |
| DOI：10.3969/j.issn.1674-3806.2009.11.15 |
| 分类号:R 516.4 |
| 基金项目: |
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| Effects of treatments with radix astragali and antibiotics on bowel function in rats after shigella flexneri infection |
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XIE Zi-ren
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The First People′s Hospital of Yulin, Guangxi 537000, China
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| Abstract: |
| ［Abstract］ Objective To observe the effects of treatments with radix astragali and antibiotics on bowel function in rats after shigella flexneri infection. Methods Forty male Wistar rats were divided into normal control, model, antibiotics-treatment, radix astragali and antibiotics combination treatment groups. Each group was given the corresponding treatment after sucescful model. At 15～20 days after treatment, the perceptual threshold was detected. Results The perceptual threshold greatly decreased in the model group and antibiotics treatment groups (P<0.05), while that of the combination treatment group had no difference from the normal control. Conclusion Shigella flexneri infection can lead to bowel sensory motor disorder that remains for a period of time after inflammation diminishes. Treatment with antibiotics single cannot normalize the functional disturbance, but a combination treatment with radix astragali and antibiotics can. |
| Key words: Infection Bowel function disorder Radix astragali Antibiotics |
