| 摘要: |
| ［摘要］ 噻唑烷二酮类药物(Thiazolidinediones,TZDs)是人工合成的高亲合性的过氧化物酶体增殖物激活受体γ(Peroxisome proliferator-activated receptors,PPARs)配体。TZDs除通过改善胰岛素抵抗、降糖作用外，尚可通过改善内皮功能、抗炎、抑制平滑肌增生和新生内膜形成、预防动脉再狭窄等方面发挥血管保护作用。 |
| 关键词: 噻唑烷二酮类药物 过氧化物酶体增殖物激活受体γ 血管 保护作用 |
| DOI：10.3969/j.issn.1674-3806.2010.02.44 |
| 分类号:R 587 |
| 基金项目: |
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| Protective effects of thiazolidinediones in the Vasculature |
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WU Xu-bin, WU Guang-wei, LIN Ying-zhong
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Department of Cardiology, the People′s Hospital of Guangxi Zhuang Autonomous Regions, Nanning 530021,China
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| Abstract: |
| ［Abstract］ The thiazolidinediones(TZDs) are peroxisome proliferator-activated receptor (PPAR)-γ agonists. In addition to improving insulin sensitivity and glycemic control, TZDs also play critical roles in the vasculature by improving endothelial dysfunction, decreasing the expression of several inflammatory mediators, inhibiting the proliferation and migration of vascular smooth muscle cells and the development of restenosis after vascular interventions. |
| Key words: Thiazolidinediones Peroxisome proliferator-activated receptors Vasculature Protective effects |
