| 摘要: |
| ［摘要］ 目的 分析丙基硫氧嘧啶(PTU)致抗中性粒细胞胞浆抗体(ANCA)相关小血管炎的机理。方法 报告3例因长期服用丙基硫氧嘧啶所致ANCA 相关小血管炎的临床资料，并复习近年相关文献加以讨论。结果 3例的临床表现主要是血尿、蛋白尿、肾功能受损、累及肺部和ANCA阳性等；3例发病前均服用PTU，故诊为PTU导致的ANCA相关小血管炎；3例均经停用PTU，给予激素和免疫抑制剂治疗症状明显好转，肾功能得到恢复。结论 PTU可导致ANCA相关小血管炎。甲亢病人使用PTU治疗时，特别是长时间、大剂量使用时，应定期进行ANCA检查；早期治疗是改善预后的关键 |
| 关键词: 丙基硫氧嘧啶 抗中性粒细胞胞浆抗体 血管炎 |
| DOI：10.3969/j.issn.1674-3806.2010.07.33 |
| 分类号:R 593.27 |
| 基金项目: |
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| Propylthiouracil_associated antineutrophil cytoplasmic antibody-positive vasculiti |
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LU Qiu-wei
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Department of Clinical Laboratory，the People′s Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021, China
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| Abstract: |
| ［Abstract］ Objective To study the pathogenesis of antineutrophil cytoplasmic antibody-positive vasculitis induced by propylthiouracil(PTU).Methods By reporting three cases of antineutrophil cytoplasmic antibody-positive vasculitis induced by PTU，the related literature was reviewed and discussion was made.Results Three cases presented with hematuria，proteinuria， renal function damage，injury of lung and positive antineutrophil cytoplasmic antibody.Three cases had been treated with PTU for months because of Graves disease.The PTU was withdrawn，and prednisone and immunosuppressant were used.After the treatment，the symptoms were maruedly improved，and the renal function returned.Conclusion PTU may induce antineutrophil cytoplasmic antibodypositive vasculilis.Early diagnosis，withdraw of PTU and administration of glucocortocoid can improve its prognosis. |
| Key words: Propylthiouracil Antineutrophil cytoplasmic antibodies Vasculitis |
