| 摘要: |
| ［摘要］ 目的 观察百令胶囊与胰激肽原酶联合治疗早期糖尿病肾病（EDN）的疗效以及治疗前后尿微量白蛋白的变化。方法 将50例早期EDN患者随机分为两组，对照组在常规治疗基础上予胰激肽原酶240 U，3次/d,口服；联合治疗组在对照组基础上加用百令胶囊1.0 g，3次/d,口服，12周和6个月后观察联合治疗组与对照组治疗前后24 h尿微量白蛋白排泄率(UAER)的变化。结果 治疗后12周,两组患者治疗前后24 h UAER均有较明显下降(P<0.05)；治疗后6个月,对照组患者治疗前后24 h UAER有一定的下降(P<0.05),联合组患者治疗前后24 h UAER有明显的下降(P<0.01)；治疗后12周和6个月组间比较，联合组24 h UAER与对照组比较差异有统计学意义(P<0.05)。结论 百令胶囊与胰激肽原酶联合应用能明显降低EDN患者的尿微量白蛋白排泄，可以有效延缓DN的进展。 |
| 关键词: 早期糖尿病肾病 24 h尿微量白蛋白排泄率 百令胶囊 胰激肽原酶 |
| DOI：10.3969/j.issn.1674-3806.2010.08.15 |
| 分类号:R 587.2 |
| 基金项目: |
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| Therapeutic efficacy of bailing capsule combined with pancreatic kininogenase in the treament of early diabetic nephropathy |
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MENG Guan-yun
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Armed Police Corps Hospital of Guangxi Border，Nanning 530003，China
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| Abstract: |
| ［Abstract］ Objective To observe the therapeutic efficacy of bailing capsule combined with pancreatic kininogenase(PK) in the treatment of early diabetic nephropathy (EDN), and the changes of urinary micro-albumin. Methods Fifty cases of EDN were randomly divided into two groups.On the bases of routine therapy， the comparison group took PK 240 U, 3 times a day orally. On the basis of the comparison group, the combined treatment group took bailing capsule 1.0 g, 3 times a day orally. The changes of 24 h urinary albumin excretion rate(UAER) in the combined treatment group and the comparison group were observed before and after 12 weeks or 6 months of treatment. Results The 24h UAER of the two groups were all decreased (P<0.05) after 12 weeks；after 6 months, the 24 h UAER of the comparison group were decreased (P<0.05)， and that of the combined treatment group decreased more significantly (P<0.01)； there was significant difference between the two groups after 12 weeks or 6 months of treatment (P<0.05). Conclusion Bailing capsule combined with PK could significantly reduced urinary micro-albumin excretion of EDN patients and effectively delay the progress of DN. |
| Key words: Early diabetic nephropathy 24 h urinary albumin excretion rate Bailing capsule Pancreatic kininogenase |
