| 摘要: |
| ［摘要］ 瘦素是肥胖基因编码,主要由脂肪细胞合成和分泌的多肽激素,通过与其受体结合发挥抑制饮食、减少能量摄入、增加能量消耗等生物学作用。心肌细胞肥大是指心肌细胞体积增大直径增宽或长度增加和肌节数量增多。心肌肥大的机制未完全阐明，目前认为各种机械刺激、化学因素作用是导致心肌肥大的主要原因。近年来瘦素与心血管疾病的关系引起广泛关注，瘦素除了有抗肥胖、维持能量平衡作用外,与心肌肥大方面有密切的关系，瘦素可能作为一个内源性物质在心肌肥大中起到重要的作用。该文就瘦素与心肌肥大的关系进行综述。 |
| 关键词: 瘦素 瘦素受体 心肌肥厚 |
| DOI：10.3969/j.issn.1674-3806.2010.09.43 |
| 分类号:R 542.2 |
| 基金项目: |
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| Progress of relationship between leptin and cardiac hypertrophy |
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WANG Xiao-shan,XU Tong-tong
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VIP Ward, the Affiliated Hospital of Guilin Medical College, Guangxi 541001, China
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| Abstract: |
| ［Abstract］ Leptin is encoded by obese gene, and it is a kind of peptide hormone mainly synthesized and secreted by fat cells. By binding its receptors, it plays the role of inhibiting diet, reducing energy intake, increasing energy expenditure, and so on. Cardiac hypertrophy refers to the myocardial cell volume increases and diameter widening or length increase and the growing number of sarcomere。At present, mechanism of cardiac hypertrophy has not been completely clarified.A variety of mechanical stimulation, chemical factors, may be the major mechanism.In recent years, the relationship between leptin and cardiovascular disease has aroused widespread concern, in addition to anti-obesity and maintenace of energy balance, leptin have a close relationship with myocardial hypertrophy.It may play an important role as an endogenous substance in cardiac hypertrophy.This paper reviews the relationship between leptin and cardiac hypertrophy. |
| Key words: Leptin Leptin receptor Cardiac hypertrophy |
