| 摘要: |
| ［摘要］ 目的 探讨白细胞介素-2联合放化疗治疗中晚期鼻咽癌的远期疗效。方法 1997-07～1999-12收治的90例鼻咽癌首诊患者随机抽签分为三组:A组为白细胞介素-2局部用药+放、化疗组;B组为白细胞介素-2全身用药+放、化疗组;C组为常规放、化疗组。比较三组患者5年生存率及10年生存率。结果 5年生存率A组为63.3%，B组为70%，C组为36.7%，A组和B组5年生存率较C组差异均有统计学意义(P<0.05)；A组与B组5年生存率比较差异无统计学意义(P>0.05)。10年生存率A组为30%，B组为50%，C组为23.3%，A组与B组、A组与C组10年生存率差异无统计学意义(P>0.05)，B组10年生存率较C组高(P<0.05)。结论 白细胞介素-2联合放、化疗组5年生存率较常规放化疗组高，而全身用药在提高远期生存率(10年)上较局部用药效果明显。 |
| 关键词: 鼻咽癌 白细胞介素-2 放化疗 远期疗效 |
| DOI：10.3969/j.issn.1674-3806.2010.11.08 |
| 分类号:R 739.63 |
| 基金项目:广西壮族自治区科技厅计划攻关基金资助项目（编号：9732023） |
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| Analysis long-term effect of interleukin 2 combined with radiochemotherapy for treating advanced nasopharyngeal carcinoma |
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ZHANG Zheng, QIN Ying,WENG Jing-jin, et al.
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DivisionⅡ,Department of Otorhinolaryngology,the People′s Hospital of Guangxi Zhuang Autonomous Region,Nanning 530021, China
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| Abstract: |
| ［Abstract］ Objective To analyse the long-term effect of interleukin 2(IL-2) combined with radiochemotherapy for treating advanced nasopharyngeal carcinoma. Methods Ninety patients with advanced nasopharyngeal carcinoma(NPC) were divided into 3 groups randomly. A group was treated by combination of local IL-2 injection with radiochemotherapy, B group was treated by combination of IL-2 systemic administration with radiochemotherapy, C group was treated by radiochemotherapy. The five-year survival rate and ten-year survival rate were observed. Results Five-year survival rate in B group (70%) were superior to those in C group (36.7%) (P<0.05) and five-year survival rate in A group (63.3%) were superior to those in C group (36.7%) (P<0.05); the ten-year survival rates in B group （50%） were superior to C group （23.3%） (P<0.05), but there was no difference of ten-year survival rates between A group and B group (P>0.05). Conclusion Combination of Interleukin 2 with radiochemotherapy can improve the survival rate of advanced NPC patient. Systemic administration of IL-2 has better effect than local administration of IL-2 for treating advanced NPC. |
| Key words: Nasopharyngeal carcinoma Interleukin 2 Radiochemotherapy Long-term effect |
