| 摘要: |
| ［摘要］ 目的 研究肿瘤转移基因EMMPRIN在非小细胞肺癌癌组织和癌旁组织中的表达及意义。方法 采用RT-PCR检测80例非小细胞肺癌癌组织和40例癌旁正常组织中EMMPRIN的表达。结果 EMMPRIN在肺癌细胞中表达阳性率高于癌旁组织，差异有统计学意义（P<0.05）,在NSCLC中，EMMPRIN表达随着肿瘤病理分级和TNM分期增加而有增高趋势。EMMPRIN的表达与有淋巴结转移呈正相关（P<0.05）。结论 EMMPRIN参与了NSCLC的发生发展过程，EMMPRIN的表达可作为判断NSCLC病理分级及转移和预后的指标，为临床诊断和治疗提供依据。 |
| 关键词: 非小细胞肺癌 RT-PCR EMMPRIN |
| DOI：10.3969/j.issn.1674-3806.2011.03.03 |
| 分类号:R 734.2 |
| 基金项目:广西回国基金资助项目（编号：桂科回0832011）；广西壮族自治区卫生厅自筹经费科研课题（编号：Z2008131） |
|
| Expression and clinical significance of EMMPRIN in tissues of non-small cell lung cancer |
|
DAI Lei，XIAN Lei，CHEN Ming-wu
|
|
Department of Cardiothoracic Sergery, the First Affiliated Hospital，Guangxi Medical University，Nanning 530021，China
|
| Abstract: |
| ［Abstract］ Objective To evaluate the expression and significance of EMMPRIN in tissues of non-small cell lung cancer (NSCLC).Methods Reverse transcription polymerase chain reaction (RT-PCR) was used for measuring the expression level of EMMPRIN in tissues from 80 patients with NSCIC and in tumor adjacent tissues from 40 patients with NSCLC.Then the sequence of PCR products of EMMPRIN gene was analysed.Results The positive expression rate of EMMPRIN in tissues of non-small cell lung cancer was significantly higher than that in tumor adjacent tissues (P<0.05). EMMPRIN expression was positively correlated with lymph node metastasis (P<0.05).Conclusion EMMPRIN may take part in the progress of NSCLC, and may be used as good indicator for judging metastasis, clinical stage, and prognosis of lung cancer. |
| Key words: Non-small cell lung cancer RT-PCR EMMPRIN |
