| 摘要: |
| ［摘要］ 脂蛋白(a)［lipoprotein(a),Lp(a)］是一种独立的脂蛋白颗粒，由肝脏合成的载脂蛋白(a)［Apolipoprotein(a),Apo(a)］分泌至循环中与LDL结合所形成。血液中的Lp(a)浓度不受性别、年龄、饮食、理化等因素及多种降脂药物的影响，是一种稳定的遗传学标志。血清Lp(a)与糖尿病肾病（diabetic nephropathy,DN）关系密切，DN患者血清Lp(a)水平显著增高，且与尿微量白蛋白排泄率（UAER）呈正相关，Lp(a)又可通过多种机理对肾脏造成损伤。在糖尿病病人中进行血清Lp(a)的监测有可能作为一种反应早期肾损伤的辅助指标应用于临床。但因其特异性差，其他肾病、心血管疾病、脂代谢紊乱性疾病及急性炎症时均可升高，需要进一步的基础和临床研究探讨。 |
| 关键词: 脂蛋白(a) 尿微量白蛋白排泄率 糖尿病肾病 诊断 |
| DOI：10.3969/j.issn.1674-3806.2011.03.31 |
| 分类号:R 587.1 |
| 基金项目: |
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| Research progress on lipoprotein(a) and the early diagnosis of diabetic nephropathy |
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ZHANG Chang-ming, LONG Yan
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Department of Endocrinology, the Affiliated Hospital of Gulin Medical College, Guangxi 541001, China
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| Abstract: |
| ［Abstract］ Lipoprotein(a)［Lp(a)］ is an independent lipoprotein particle, composed of apolipoprotein(a)［Apo(a)］ and low density lipoprotein(LDL). Lp(a)′s concentration in serum is stable, cannot be changed with sex, age, diet, physical or chemical factors or drugs, is one of serum genetic marks. Reseach shows there is close relations between serum Lp(a) and diabetic nephropathy(DN). The level of Lp(a) in DN patients increase remarkably, and show positive correlation with urinary albumin excretion rate(UAER). Lp(a) damage kidney by many mechanisms. The analysis of Lp(a) in diabetes mellitus patients would be one of the adjunctive methods in the early diagnosis of DN. However, serum Lp(a) can increase in other renal diseases, cardiovascular diseases, disturbance of lipid metabolism and acute inflammation, more basic and clinical study are essential to improve the specificity of the detection. |
| Key words: Lipoprotein(a)［Lp(a)］ Urinary albumin excretion rate(UAER) Diabetic nephropathy(DN) Diagnosis |
