| 摘要: |
| ［摘要］ 目的 探讨血清脂蛋白(a)［Lipoprotein(a)，LP(a)］测定对临床早期糖尿病肾病(Diabetic nephropathy，DN)的意义。方法 根据24 h尿白蛋白排泄率(UAER)将118例糖尿病患者分为糖尿病无肾病组（A组，41例，UAER<30 mg/24 h）、临床早期DN组（B组，39例，30 mg/24 h≤UAER<300 mg/24 h）及临床DN组（C组，38例，UAER≥300 mg/24 h）。从同期门诊健康体检者中随机选择40例为对照组（D组）。分别测定各组UAER及血清Lp(a)。各组均数的比较用方差分析，各组分别比较UAER和Lp(a)间的直线相关性。结果 糖尿病各组与对照组比较血清Lp(a)升高(A组与D组比P<0.05，B、C组与D组比P<0.01)，且随DN之肾脏病变进展(UAER增加)而递增(B组与A组比P<0.01，C组与B组比P<0.05)。A组与B组血清Lp(a)水平与UAER呈直线正相关(A组r=0.356,P<0.05；B组r=0.438,P<0.01)。结论 血清Lp(a)水平与DN肾损害程度相关，可以作为诊断早期DN的辅助方法之一。 |
| 关键词: 糖尿病肾病 脂蛋白(a) 尿白蛋白排泄率 |
| DOI：10.3969/j.issn.1674-3806.2011.05.13 |
| 分类号:R 587.1 |
| 基金项目: |
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| Value of serum Lp(a) detection in the diagnosis of early diabetic nephropathy |
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ZHANG Chang-ming, LONG Yan, SU Ke, et al.
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Department of Endocrinology,Affiliated Hospital of Guilin Medical College,Guangxi 541001,China
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| Abstract: |
| ［Abstract］ Objective To investigate the clinical significance of analysis of serum Lipoprotein(a)［Lp(a)］ level in diagnosis of early diabetic nephropathy(DN). Methods One hundred and eighteen patients with diabetes mellitus were divided into 3 groups according to 24-hour urinary albumin excretion rate(UAER): group A(patients without DN), 41, UAER<30 mg/24 h; group B(early DN), 39, 30 mg/24 h≤UAER<300 mg/24 h; group C(clinical DN), 38, UAER≥300 mg/24 h. Forty healthy volunteers were as control group(group D). The UAER and serum Lp(a) were tested in all patients. The results were analyzed with ANOVA and Linear correlation. Results The serum Lp(a) level of group A, B, C was higher than that of group D（group A vs. D, P<0.05，group B and C vs. D, P<0.01）, and was increasing with the progression of DN (group B vs. A, P<0.01，group C vs. B, P<0.05).The level of Lp(a) of group A and B were positive linear correlation with UAER(group A, r=0.356, P< 0.05；group B, r=0.438, P<0.01).Conclusion Serum Lp(a) level may be related with the lesion of DN, the analysis of Lp(a) would be one of the adjunctive methods in the diagnosis of the early stage of this disease. |
| Key words: Diabetic nephropathy(DN) Lipotrotein(a)［Lp(a)］ Urinary albumin excretion rate(UAER) |
