| 摘要: |
| ［摘要］ 目的 观察较大剂量普伐他汀治疗心肌梗死患者3 d后C反应蛋白（CRP）、基质金属蛋白酶-9（MMP-9）的变化。方法 72例急性心肌梗死患者分为A、B两组，每组36例，A组口服普伐他汀片40 mg/d，B组口服普伐他汀片20 mg/d，治疗前及治疗3 d后分别测定CRP和MMP-9。结果 两组患者血清CRP和MMP-9在治疗后3 d均有明显下降（P<0.05），但以40 mg普伐他汀组更明显(P<0.01)。结论 急性心肌梗死早期使用普伐他汀可抑制患者炎性反应，且较大剂量效果更好。 |
| 关键词: 心肌梗死 普伐他汀 炎性因子 |
| DOI：10.3969/j.issn.1674-3806.2012.03.04 |
| 分类号:R 542.2+2 |
| 基金项目:广西自然科学基金资助项目（编号：桂科自0542060） |
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| Effect of large dose of pravastatin on serum CRP and MMP-9 level in patients of acute myocardial infarction |
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CHEN Ying, DUAN Xiao-yan, ZHANG Shu-feng, et al.
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Department of Cardiovasoloy,Guangxi Jiangbin Hospital, Nanning 530021, China
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| Abstract: |
| ［Abstract］ Objective To observe the effects of large does of pravastatin on the charnge of C reactive protein (CRP),Matrix metalloproteinase-9(MMP-9) in acute myocardial infarction patients.Methods 72 patients with acute myocardial infaction were divided into two groups: the group A were administered orally pravastatin 40 mg/d and the group B were administered orally pravastatin 20 mg/d. The serum levels of CRP, MMP-9 were measured at the end of the treatment.Results The two groups serum levels of CRP、MMP-9 were significantly decreased at the end of the 3th day(P<0.05),and the group A was superior to group B.Conclusion The inflammatory reaction could be inhibited in acute myocardial infarction patients treated with pravastatin. |
| Key words: Myocardial infarction Pravastatin Inflammatory makers |
