| 摘要: |
| ［摘要］ 目的 探讨血清胆碱酯酶（CHE）在慢性乙型肝炎病毒感染中的临床意义。方法 将317例慢性乙型肝炎病毒感染患者分成三组，即慢性乙型肝炎组111例、肝硬化组108例、肝癌组98例，将排除慢性肝肾病史的健康体检者110名作为正常对照组，均作CHE、血清丙氨酸氨基转移酶（ALT）、白蛋白（Alb)、总胆红素（TBIL）和胆固醇（Chol)水平测定。结果 慢性乙型肝炎组、肝硬化组和肝癌组的CHE水平均明显低于正常对照组，其中肝硬化和肝癌组降低更为明显（P<0.01）。Child-Pugh C级的肝硬化患者CHE水平最低，与Chid-Pugh A级和B级患者比较差异均有统计学意义（P<0.05）。结论 胆碱酯酶反映慢性乙型肝炎病毒感染患者肝损害程度较敏感，动态观察胆碱酯酶的变化对判断慢性乙型肝炎病毒感染患者的预后有重要意义。 |
| 关键词: 慢性乙型肝炎病毒 胆碱酯酶 |
| DOI：10.3969/j.issn.1674-3806.2012.04.07 |
| 分类号:R 575.1 |
| 基金项目: |
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| The clinical significance of serum cholinesterase levels in patients with chronic hepatitis B virus |
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DENG Zhi-hai
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Department of Infections Diseases,the Lingui Affiliated Hospital of Guilin Medical College,Guangxi 541199,China
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| Abstract: |
| ［Abstract］ Objective To study the clinical significance of serum cholinesterase in patients with chronic hepatitis B virus.Methods Totally 317 patients with chronic hepatitis B virus were randomly assigned to a chronic hepatitis B group (n=111),a liver cirrhosis group (n=108) and a liver cancer group (n=98),and the control group was composed of 110 with healthy cases without liver and renal chronic diseases. the serum cholinesterase, ALT, ALB, TBIL, Chol were desermined.Results The serum cholinesterase of chronic hepatitis B group, liver cirrhosis group and liver cancer group was lower than that of control group, in liver cirrhosis group and liver cancer group was more lower, the liver cirrhosis of Child-Pugh C class was the lowest, the differences between Child-Pugh A class and Child-Pugh B class were significant (P<0.05).Conclusion Determination of levels of serum cholinesterase might reflect the degree of liver inflammation and fibrosis in patients with chronic hepatitis B virus,the change of cholinesterase is very important factor influencing prognosis. |
| Key words: Chronic hepatitis B virus Cholinesterase |
