| 摘要: |
| ［摘要］ 目的 探讨白细胞介素-8（IL-8）和血管内皮细胞生长因子（VEGF）蛋白表达在鼻咽非角化性癌发生发展中的意义。方法 应用免疫组化S-P法检测15例鼻咽黏膜慢性炎和80例鼻咽非角化性癌中IL-8和VEGF的表达，分析两者的相关性及与临床病理指标的关系。结果 黏膜慢性炎组织IL-8和VEGF阳性率均为20%（3/15），而鼻咽非角化性癌中IL-8和VEGF的阳性率分别为67.5%（54/80）和65%（52/80），IL-8和VEGF在鼻咽非角化性癌中的阳性率均明显高于黏膜慢性炎组织（P<0.05）；IL-8与VEGF表达呈正相关（r=0.328，P<0.05）；IL-8和VEGF与性别、年龄、颈部淋巴结转移、病理类型、临床分期等临床病理特征无相关性。结论 IL-8和VEGF在鼻咽非角化性癌中存在过表达，在鼻咽非角化性癌发生发展中可能起协同作用。 |
| 关键词: 鼻咽肿瘤 白细胞介素-8 血管内皮细胞生长因子 免疫组化 临床病理特征 |
| DOI：10.3969/j.issn.1674-3806.2012.08.01 |
| 分类号:R 739.63;R 766.3 |
| 基金项目:广西自然科学基金资助项目(编号：桂科自0542072) |
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| The expression and clinical significance of IL-8 and VEGF in nasopharyngeal non-keratinizing carcinomas |
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LI Hua, WEI Min-yi, LIANG Xiu-jiu, et al.
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Department of Pathology, the Affiliated Ruikang Hospital of College of Traditional Chinese Medicine, Guangxi 530011, China
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| Abstract: |
| ［Abstract］ Objective To explore the role of IL-8 and VEGF in the pathogenesis and development of nasopharyngeal non-keratinizing carcinoma(NPC). Methods Expression of IL-8 and VEGF was examined by S-P immunohistochemistry in 80 NPC archival paraffin-embedded tissue specimens and 15 controlled chronic nasopharyngitis mucosa. The relationship between clinicopathological features and expression of IL-8 and VEGF were also analyzed.Results Expression rates of IL-8 and VEGF in NPC cases and were 67.5%（54/80） and 65%（52/80）, respectively, versus 20%（3/15） for both IL-8 and VEGF in chronic nasopharyngitis. The expression rates of the IL-8 and VEGF in NPC were significantly higher than that in chronic nasopharyngitis (P <0.05). There was positive correlation between the expression of IL-8 and VEGF（r=0.328, P <0.05）. No correlation was found between the expression of IL-8 and VEGF with patients′ clinicopathological features as to gender, age, lymph node metastasis, histotype and TNM stages.Conclusion IL-8 and VEGF are over-expressed in NPC, and maybe cooperate as angiogenesis factors in the pathogenesis and development of NPC. |
| Key words: Nasopharyngeal neoplasms IL-8 VEGF Immunohistochemistry Clinicopathological features |
