| 摘要: |
| ［摘要］ 目的 探讨慢性鼻窦炎（chronic rhinosinusities with nasal polyp,CRSWNP）伴鼻息肉患者鼻息肉组织中总IgE表达与IgE介导Ⅰ型变态反应的关系。方法 使用免疫组织化学技术分别检测40例CRSWNP患者（CRSWNP组，其中合并变应性因素亚组和无变应性因素亚组各20例）的鼻息肉组织和20例鼻中隔偏曲患者（对照组）的中鼻甲组织中总IgE表达，并与鼻窦CT的Lund-Mackay评分相关性进行统计学分析。结果 CRSWNP组总IgE阳性细胞数为（14.65±3.34），显著高于对照组的（3.40±1.27）（P<0.01）；合并变应性因素与无变应性因素患者间总IgE表达差异无统计学意义（P>0.05）；CRSWNP组鼻窦CT的Lund-Mackay评分为（12.35±4.26），与IgE的表达呈正相关（r=0.464，P<0.05）。结论 鼻息肉组织总IgE高表达参与CRSWNP的发病，其导致的局部炎症反应也许存在与IgE介导的I型变态反应不同的作用途径。 |
| 关键词: 慢性鼻窦炎 鼻息肉 变态反应和免疫学 免疫球蛋白E |
| DOI：10.3969/j.issn.1674-3806.2012.08.03 |
| 分类号:R 765 |
| 基金项目:广西自然科学基金资助项目（编号：桂科青0728040） |
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| The expression of tatol IgE in nasal polyp and its relationship with hypersensitivity reaction type Ⅰ mediated by IgE |
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HE Ning, LIANG Jian-ping,CHEN Jun,et al.
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Department of Otolaryngology-Head and Neck Oncology, the People′s Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021, China
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| Abstract: |
| ［Abstract］ Objective To investigate the expression of total IgE in nasal polyps in patieats of chronic rhinosinusities with nasal polyg(CRSWNP) and its relationship with hypersensitivity reaction type I mediated by IgE.Methods The expression of total IgE protein in nasal polyps tissue in 40 cases of CRSWNP(20 cases with and 20 cases without allergic rhinitis) nasal polyps tissue(the CRSWNP group) and 20 middle turbinate tissue samples(the control group) were examined by immunohistochemistry.All cases were scored with Lund-Mackay CT system in CRSWNP group and analyzed statistically.Results The positive stainning cells of total IgE protein in nasal polyps tissue in CRSWNP group was (14.65±3.34), which was significant higher than that in control group （3.40±1.27）(P<0.01),the expression of total IgE in nasal polyps with and without allergic rhinitis in CRSWNP was 14.69±2.67 and 14.58±4.31 respectively,no significant statistical difference in the expression of total IgE was found between them.There was a positive correlation between the expression of total IgE and Lund-Mackay CT system scores （12.35±4.26） in CRSWNP group (r=0.464，P<0.05).Conclusion The overexpression of total IgE palys a role in CRSWNP,that may be different with hypersensitivity reaction type I mediated by IgE. |
| Key words: Chronic rhinosinusities Nasal polyp Allergy and Immunology Immunoglobulin E |
