| 摘要: |
| ［摘要］ 目的 探讨血清胱抑素C（Cys-C）和β2微球蛋白（β2-MG）联合检测对过敏性紫癜（HSP）早期肾损伤诊断的临床价值。方法 选择明确诊断为HSP患儿45例，采用颗粒增强透射免疫比浊法测定血清Cys-C，放射免疫法测定血β2-MG，并与健康对照组进行比较。结果 HSP患儿Cys-C、β2-MG水平均显著高于健康对照组（P<0.01），联合检测的阳性率明显高于单项检测（P<0.01）。结论 血清Cys-C和β2-MG可作为HSP早期肾损伤的检测指标，联合检测能提高阳性率。 |
| 关键词: 过敏性紫癜 血清胱抑素C β2微球蛋白 早期肾脏损伤 |
| DOI：10.3969/j.issn.1674-3806.2012.10.11 |
| 分类号:R 720.5 |
| 基金项目: |
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| The value of combined detection of cystatin C and β2-microglobulin in predicting early renal damage of children with Henoch-Schnlein purpura |
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LIU Dong-li,FAN Shu-hong
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Department of Pediatrics,the People′s Hospital of Queshan County,Henan 463200,China
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| Abstract: |
| ［Abstract］ Objective To study the value of combined detection of cystatin C and β2-microglobulin(β2-MG) in predicting early renal damage of children with Henoch-Schnlein purpura（HSP）.Methods Forty-five children with HSP were selected. The particle enhanced transmission turbidimetric immunoassay was used for detecting serum cystatin (Cys C) and radio immunoassay for serum β2-MG.The results were compared with those of healthy control group.Results The levels of serum Cys C and β2-MG in children with HSP were higher than those of healthy control group（P<0.01）. The positive rate of combined detection was obviously higher than that of single detection (P<0.01).Conclusion Serum Cys-C and β2-MG can be used as the detection indexes of early renal damage，and combined detection can improve the positive rate. |
| Key words: Henoch-Schnlein purpura（HSP） Cystatin C β2-microglobulin (β2-MG) Early renal damage |
