| 摘要: |
| ［摘要］ 目的 研究充血性心力衰竭患者血浆脑钠肽（BNP）与心功能的关系，探讨BNP在充血性心力衰竭的诊断、预后评估中的作用。方法 收集充血性心力衰竭患者82例以及正常健康受试者30名，行心脏彩超多普勒超声测定心脏左室射血分数，莹光免疫测定法测定血浆BNP水平；随访2年并进行生存分析。结果 充血性心力衰竭患者血浆BNP水平高于正常健康受试者（P<0.05），同时BNP与心功能呈负相关；生存分析结果提示入院时BNP水平与2年终点事件发生有关。结论 BNP水平与心功能有密切关系，可用于充血性心力衰竭的诊断，同时有助于预后的评估。 |
| 关键词: 充血性心力衰竭 脑钠肽 射血分数 随访 |
| DOI：10.3969/j.issn.1674-3806.2012.10.23 |
| 分类号:R 541.6+1 |
| 基金项目: |
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| The relationship between brain natriuretic peptide and cardiac function and prognostic value of brain natriuretic peptide in congestive heart failure patients |
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XIE Feng
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Department of Internal Medicine,Dongsheng Hospital of Zhongshan, Guangdong 528414,China
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| Abstract: |
| ［Abstract］ Objective To investigate the relationship of brain natriuretic peptide(BNP) and cardiac function in congestive heart failure patients and the role of BNP in diagnosis, prognosis assessment in congestive heart failure.Methods Eighty-two congestive heart failure patients and 30 normal subjects were collected. Cardiac left ventricular ejection fraction was assessed by cardiac color Doppler ultrasound; plasma BNP levels was measured by fluorescence immunoassay;the patients were followed up for 2 years and survival analysis was performed.Results The plasma BNP levels in patients with heart failure is far higher than that in the normal healthy subjects（P<0.05）,and BNP negatively related to cardiac function; survival analysis showed that BNP levels was closely related to two end-point events.Conclusion BNP levels and cardiac function is related, and BNP can be used for diagnosis and the prognosis assessment of congestive heart failure patients. |
| Key words: Congestive heart failure Brain natriuretic peptide(BNP) Ejection fraction Follow up |
