| 摘要: |
| ［摘要］ 原发性中枢神经系统淋巴瘤是一种较罕见的中枢神经系统恶性肿瘤，具有不向中枢神经系统轴以外播散、生物学行为具有侵袭性、病理形态存在异质性、临床无典型性、影像表现多样性、实验室检查无特异性的特点，依靠病理免疫组化及分子生物学方可确诊。对手术切除分歧较大，虽然对放射及化学药物治疗敏感，但缺乏共识方案，较全身及其他部位淋巴瘤预后差。该文就原发性中枢神经系统淋巴瘤的诊治进展作一综述。 |
| 关键词: 原发性中枢神经系统淋巴瘤 诊断 治疗 |
| DOI：10.3969/j.issn.1674-3806.2012.12.32 |
| 分类号:R 739.4 |
| 基金项目: |
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| Research progress on diagnosis and treatment of primary central nervous system lymphoma |
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HUANG Ling-tuan,TAN Yi
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Department of Neurosurgery,Guangxi Brain Hospital,Liuzhou 545005,China
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| Abstract: |
| ［Abstract］ Primary central nervous system lymphoma(PCNSL)is a rare form of non-Hodgkin lymphoma (NHL)that is restricted entirely to CNS without evidence of systemic spread and that has aggressive biological behavior.Due to absence of typical clinical presentation,multiple neuroimaging appearance,heterogeneity of pathological morphology and without specific laboratory examination so on,the immunohistochemistry and molecular biology are of vital importance in accurate diagnosis of this disease.At present,the methods of treatment include operation,chemotherapy,radiotherapy,immunotherapy and so on.The excision of intracranial tumor is discussed.Although the introduction of systemic chemotherapy and radiotherapy has consistently improved survival,the prognosis of PCNSL is still poor.This paper reviews the research progress on diagnosis and treatment of PCNSL. |
| Key words: Primary central nervous system lymphoma Diagnosis Therapy |
