| 摘要: |
| ［摘要］ 目的 探讨非霍奇金淋巴瘤（NHL）患者血清乳酸脱氢酶（LDH）及β2-微球蛋白（β2-MG）水平检测与临床诊断、分期及治疗效果的关系。方法 筛选32例初诊为NHL患者为观察组，其中Ⅰ期5例，Ⅱ期7例，Ⅲ期9例，Ⅳ期11例。以35名健康体检者为正常对照组。全部入组对象均采集清晨空腹静脉血检测LDH、β2-MG值。结果 (1)NHL血清LDH及β2-MG水平明显高于对照组(P<0.01)；(2)Ⅲ+Ⅳ期患者血清LDH及β2-MG水平明显高于Ⅰ+Ⅱ期患者(P<0.01)；(3)化疗2个疗程后，其血清LDH及β2-MG水平较治疗前明显降低(P<0.01)。结论 血清LDH及β2-MG水平检测可作为NHL诊断、分期、疗效评估的参考指标。 |
| 关键词: 非霍奇金淋巴瘤 乳酸脱氢酶 β2-微球蛋白 |
| DOI：10.3969/j.issn.1674-3806.2013.03.10 |
| 分类号:R 446.1 |
| 基金项目: |
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| The determination of serum LDH and β2-MG in patients with non-Hodgkin’s lymphoma and its clinical significance |
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GU Ai-hu,KOU Ke-ren, WANG Yong,et al.
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Department of Oncology,the First People’s Hospital of Wuhu，Anhui 241001,China
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| Abstract: |
| ［Abstract］ Objective To study the relationship between the serum level of LDH, β2-MG and clinical diagnosis,stage and effectiveness of treatment in patients with non-Hodgkin lymphoma(NHL).Methods The level of serum LDH and β2-MG in 32 patients with NHL(NHL group) and 35 healthy subjects(control group)were detected respectively.Results (1)The level of serum LDH and β2-MG in NHL group were obviously higher than those in the control group（P<0.01）；(2)The level of serum LDH and β2-MG in Ⅲ+Ⅳstage were obviously higher than that in Ⅰ+Ⅱ stage（P<0.01）；(3) After two cycles of chemotherapy,there was statistical difference between prechemotherapy and postchemotherapy (P<0.01).Conclusion The levels of serum LDH and β2-MG can be taked as an reference index for diagnosis, classification, effectiveness of treatment in the patients with NHL. |
| Key words: Non-Hodgkin’s lymphoma(NHL) Lactic dehydrogenese(LDH) Beta-microglobulin(β2-MG) |
